Differin and Chills - a phase IV clinical study of FDA data

Summary:

Chills is reported as a side effect among people who take Differin (adapalene), especially for people who are female, 10-19 old, also take Ortho Tri-Cyclen, and have Depression.

The phase IV clinical study analyzes which people have Chills when taking Differin. It is created by eHealthMe based on reports of 5,708 people who have side effects when taking Differin from the FDA, and is updated regularly.

What is Differin?

Differin has active ingredients of adapalene. It is often used in acne. eHealthMe is studying from 5,740 Differin users. Check the latest studies of Differin.

What is Chills?

Chills (felling of cold) is found to be associated with 2,576 drugs and 3,470 conditions by eHealthMe. Check the latest studies of Chills.

On Jun, 20, 2026

5,708 people reported to have side effects when taking Differin.
Among them, 11 people (0.19%) have Chills.

Among these 11 people:

What is the gender of people who have Chills when taking Differin? *

female: 90.91 %
male: 9.09 %

What is the age of people who have Chills when taking Differin? *

What are other drugs people take besides Differin? *

What are other side effects people have besides Chills? *

Abdominal Pain Upper: 9 people, 81.82%
Nausea (feeling of having an urge to vomit): 8 people, 72.73%
Fever: 7 people, 63.64%
Fatigue (feeling of tiredness): 6 people, 54.55%
Personality Change: 6 people, 54.55%
Joint Pain: 6 people, 54.55%
Weight Decreased: 6 people, 54.55%
Feeling Abnormal: 6 people, 54.55%
Nasopharyngitis (inflammation of the nasopharynx): 6 people, 54.55%
Back Pain: 6 people, 54.55%

What are the existing conditions these people have? *

Depression: 4 people, 36.36%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 18.18%
Lichen Planus (an inflammatory skin condition, characterized by an itchy, non-infectious rash): 2 people, 18.18%
Premenstrual Syndrome: 1 person, 9.09%
Fungal Nail Infection: 1 person, 9.09%
Birth Control: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Differin and have Chills?

- Check whether Chills is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Differin:

Differin (5,740 reports)

Chills treatments and more:

Chills (145,628 reports)

Browse all side effects of Differin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Chills:

Chills (2,576 drugs)

Browse all the conditions that are associated with Chills:

Chills (3,470 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on adapalene (the active ingredients of Differin) and Differin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.