Differin and Ear barotrauma - a phase IV clinical study of FDA data

Summary:

Ear barotrauma is reported as a side effect among people who take Differin (adapalene), especially for people who are female, also take Norco, and have Osteoporosis.

The phase IV clinical study analyzes which people have Ear barotrauma when taking Differin. It is created by eHealthMe based on reports of 5,708 people who have side effects when taking Differin from the FDA, and is updated regularly.

What is Differin?

Differin has active ingredients of adapalene. It is often used in acne. eHealthMe is studying from 5,740 Differin users. Check the latest studies of Differin.

What is Ear barotrauma?

Ear barotrauma (discomfort and possible damage in the ear due to pressure differences between the inside and outside of the eardrum) is found to be associated with 300 drugs and 624 conditions by eHealthMe. Check the latest studies of Ear barotrauma.

On Jul, 03, 2026

5,708 people reported to have side effects when taking Differin.
Among them, 16 people (0.28%) have Ear barotrauma.

Among these 16 people:

What is the gender of people who have Ear barotrauma when taking Differin? *

female: 100 %
male: 0.0 %

What are other drugs people take besides Differin? *

What are other side effects people have besides Ear barotrauma? *

Immunodeficiency: 16 people, 100.00%
Jaundice - Yellow Skin (a yellowish pigmentation of the skin): 16 people, 100.00%
Impaired Gastric Emptying: 16 people, 100.00%
Injury: 16 people, 100.00%
Disability: 16 people, 100.00%
Intervertebral Disc Degeneration (spinal disc degeneration): 16 people, 100.00%
Depression: 16 people, 100.00%
Intervertebral Disc Protrusion (spinal disc protrusion): 16 people, 100.00%
Joint Swelling: 16 people, 100.00%
Chronic Renal Failure (kidney failure): 16 people, 100.00%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 16 people, 100.00%
Sinus Disorder (disease of sinus): 1 person, 6.25%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Differin and have Ear barotrauma?

- Check whether Ear barotrauma is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Differin:

Differin (5,740 reports)

Ear barotrauma treatments and more:

Ear barotrauma (1,478 reports)

Browse all side effects of Differin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Ear barotrauma:

Ear barotrauma (300 drugs)

Browse all the conditions that are associated with Ear barotrauma:

Ear barotrauma (624 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on adapalene (the active ingredients of Differin) and Differin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.