Differin and Flu - a phase IV clinical study of FDA data

Summary:

Flu is reported as a side effect among people who take Differin (adapalene), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Tamiflu, and have Hyperuricaemia.

The phase IV clinical study analyzes which people have Flu when taking Differin. It is created by eHealthMe based on reports of 5,708 people who have side effects when taking Differin from the FDA, and is updated regularly.

What is Differin?

Differin has active ingredients of adapalene. It is often used in acne. eHealthMe is studying from 5,740 Differin users. Check the latest studies of Differin.

What is Flu?

Flu (chills, fever, runny nose, sore throat, muscle pains, headache (often severe), coughing, weakness/fatigue and general discomfort) is found to be associated with 2,372 drugs and 2,703 conditions by eHealthMe. Check the latest studies of Flu.

On May, 24, 2026

5,708 people reported to have side effects when taking Differin.
Among them, 11 people (0.19%) have Flu.

Among these 11 people:

How long have people been on Differin when they have Flu? *

What is the gender of people who have Flu when taking Differin? *

female: 70 %
male: 30 %

What is the age of people who have Flu when taking Differin? *

What are other drugs people take besides Differin? *

What are other side effects people have besides Flu? *

Thrombocytopenia (decrease of platelets in blood): 4 people, 36.36%
Hallucination, Auditory (perceiving sounds without auditory stimulus): 3 people, 27.27%
Nausea (feeling of having an urge to vomit): 3 people, 27.27%
Cerebral Haemorrhage (bleeding within the brain): 3 people, 27.27%
Diarrhea: 3 people, 27.27%
White Blood Cell Count Decreased: 2 people, 18.18%
Constipation: 2 people, 18.18%
Headache (pain in head): 2 people, 18.18%
Initial Insomnia (feeling of inadequate or poor-quality sleep): 2 people, 18.18%
Limb Asymmetry (consistent task discrepancy between the two lower limbs): 2 people, 18.18%

What are the existing conditions these people have? *

Hyperuricaemia (level of uric acid in the blood that is abnormally high): 4 people, 36.36%
Haemorrhoids (a swollen vein or group of veins in the region of the anus): 3 people, 27.27%
Drowsiness: 3 people, 27.27%
Constipation: 3 people, 27.27%
Aplastic Anemia: 3 people, 27.27%
Failure To Thrive (inadequate weight gain and physical growth in children): 2 people, 18.18%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 9.09%
Renal Impairment (severely reduced kidney function): 1 person, 9.09%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 9.09%
Multiple Myeloma (cancer of the plasma cells): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Differin and have Flu?

- Check whether Flu is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Differin:

Differin (5,740 reports)

Flu treatments and more:

Flu (145,738 reports)

Browse all side effects of Differin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Flu:

Flu (2,372 drugs)

Browse all the conditions that are associated with Flu:

Flu (2,703 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on adapalene (the active ingredients of Differin) and Differin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.