Differin and Kernicterus - a phase IV clinical study of FDA data

Summary:

We study 5,775 people who take Differin (adapalene) or have Kernicterus. No report of Kernicterus is found in people who take Differin.

The phase IV clinical study is created by eHealthMe based on reports from the FDA, and is updated regularly.

What is Differin?

Differin has active ingredients of adapalene. It is often used in acne. eHealthMe is studying from 5,740 Differin users. Check the latest studies of Differin.

What is Kernicterus?

Kernicterus (a bilirubin-induced brain dysfunction) is found to be associated with 6 drugs and 48 conditions by eHealthMe. Check the latest studies of Kernicterus.

On Nov, 11, 2025

No report is found.

Do you take Differin and have Kernicterus?

- Check whether Kernicterus is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Differin:

Differin (5,740 reports)

Kernicterus treatments and more:

Kernicterus (35 reports)

How severe was Kernicterus and when was it recovered:

Kernicterus in Differin

Expand to all the drugs that have ingredients of adapalene:

Kernicterus and drugs with ingredients of adapalene

Browse all side effects of Differin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Kernicterus:

Kernicterus

Browse all the conditions that are associated with Kernicterus:

Kernicterus

Drugs similar to Differin and Kernicterus :

How the study uses the data?

The study uses data from the FDA. It is based on adapalene (the active ingredients of Differin) and Differin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.