Differin and Skin disorder - a phase IV clinical study of FDA data

Summary:

Skin disorder is reported as a side effect among people who take Differin (adapalene), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Dupixent, and have Dermatitis atopic.

The phase IV clinical study analyzes which people have Skin disorder when taking Differin. It is created by eHealthMe based on reports of 5,708 people who have side effects when taking Differin from the FDA, and is updated regularly.

What is Differin?

Differin has active ingredients of adapalene. It is often used in acne. eHealthMe is studying from 5,740 Differin users. Check the latest studies of Differin.

What is Skin disorder?

Skin disorder (skin disease) is found to be associated with 1,543 drugs and 1,450 conditions by eHealthMe. Check the latest studies of Skin disorder.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

5,708 people reported to have side effects when taking Differin.
Among them, 13 people (0.23%) have Skin disorder.

Among these 13 people:

How long have people been on Differin when they have Skin disorder? *

What is the gender of people who have Skin disorder when taking Differin? *

female: 90.91 %
male: 9.09 %

What is the age of people who have Skin disorder when taking Differin? *

What are other drugs people take besides Differin? *

What are other side effects people have besides Skin disorder? *

Rashes (redness): 5 people, 38.46%
Itching: 4 people, 30.77%
Dry Skin: 3 people, 23.08%
Dizziness: 3 people, 23.08%
Scratch: 2 people, 15.38%
Skin Exfoliation (removal of the oldest dead skin cells): 2 people, 15.38%
Pain Of Skin: 2 people, 15.38%
Skin Burning Sensation: 2 people, 15.38%
Skin Discoloration: 2 people, 15.38%
Skin Haemorrhage (bleeding into skin): 2 people, 15.38%

What are the existing conditions these people have? *

Infection: 2 people, 15.38%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 2 people, 15.38%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 7.69%
Osteoporosis (bones weak and more likely to break): 1 person, 7.69%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 7.69%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 7.69%
Insomnia (sleeplessness): 1 person, 7.69%
Acne Cystic (skin problems that cause pimples): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Differin and have Skin disorder?

- Check whether Skin disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Differin:

Differin (5,740 reports)

Skin disorder treatments and more:

Skin disorder (41,532 reports)

Browse all side effects of Differin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Skin disorder:

Skin disorder (1,543 drugs)

Browse all the conditions that are associated with Skin disorder:

Skin disorder (1,450 conditions)

Related publications that referenced our studies

Moftah NH, Kamel AM, Attia HM, El-Baz MZ, El–Moty HM, "Skin diseases in patients with primary psychiatric conditions: a hospital based study", Journal of epidemiology and global health, 2013 Sep .
Moftah NH, Kamel AM, Attia HM, El-Baz MZ, El–Moty HM, "Skin diseases in patients with primary psychiatric conditions: a hospital based study", Journal of epidemiology and global health, 2013 Sep .

How the study uses the data?

The study uses data from the FDA. It is based on adapalene (the active ingredients of Differin) and Differin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.