Differin and Systemic sclerosis (scleroderma) - a phase IV clinical study of FDA data

Summary:

Systemic sclerosis (scleroderma) is reported as a side effect among people who take Differin (adapalene), especially for people who are female, 50-59 old, have been taking the drug for 6 - 12 months also take Nizoral, and have Hypersensitivity.

The phase IV clinical study analyzes which people have Systemic sclerosis (scleroderma) when taking Differin. It is created by eHealthMe based on reports of 5,708 people who have side effects when taking Differin from the FDA, and is updated regularly.

What is Differin?

Differin has active ingredients of adapalene. It is often used in acne. eHealthMe is studying from 5,740 Differin users. Check the latest studies of Differin.

What is Systemic sclerosis (scleroderma)?

Systemic sclerosis (scleroderma) (an autoimmune or connective tissue disease. it is characterized by thickening of the skin) is found to be associated with 497 drugs and 857 conditions by eHealthMe. Check the latest studies of Systemic sclerosis (scleroderma).

On Jun, 19, 2026

5,708 people reported to have side effects when taking Differin.
Among them, 14 people (0.25%) have Systemic sclerosis (scleroderma).

Could Differin cause Systemic sclerosis (scleroderma)?

Among these 14 people:

How long have people been on Differin when they have Systemic sclerosis (scleroderma)? *

What is the gender of people who have Systemic sclerosis (scleroderma) when taking Differin? *

female: 100 %
male: 0.0 %

What is the age of people who have Systemic sclerosis (scleroderma) when taking Differin? *

What are other drugs people take besides Differin? *

What are other side effects people have besides Systemic sclerosis (scleroderma)? *

Renal Disorder (kidney disease): 14 people, 100.00%
Depression: 14 people, 100.00%
Osteomyelitis (infection of bone): 14 people, 100.00%
Periodontitis (inflammation of the tissue around the teeth): 14 people, 100.00%
Raynaud's Phenomenon (discoloration of the fingers, toes, and occasionally other areas): 14 people, 100.00%
Aseptic Necrosis (the death of bone tissue due to a lack of blood supply): 10 people, 71.43%
Fatigue (feeling of tiredness): 9 people, 64.29%
Chronic Renal Failure (kidney failure): 9 people, 64.29%
Back Pain: 9 people, 64.29%
Neck Pain: 9 people, 64.29%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 7 people, 50.00%
Osteopenia (a condition where bone mineral density is lower than normal): 7 people, 50.00%
Hypersensitivity: 7 people, 50.00%

* Approximation only. Some reports may have incomplete information.

Do you take Differin and have Systemic sclerosis (scleroderma)?

- Check whether Systemic sclerosis (scleroderma) is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Differin:

Differin (5,740 reports)

Browse all side effects of Differin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Systemic sclerosis (scleroderma):

Systemic sclerosis (scleroderma) (497 drugs)

Browse all the conditions that are associated with Systemic sclerosis (scleroderma):

Systemic sclerosis (scleroderma) (857 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on adapalene (the active ingredients of Differin) and Differin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.