Differin and Thin bones - a phase IV clinical study of FDA data

Summary:

Thin bones is reported as a side effect among people who take Differin (adapalene), especially for people who are female, 20-29 old, also take Amoxicillin, and have Acne cystic.

The phase IV clinical study analyzes which people have Thin bones when taking Differin. It is created by eHealthMe based on reports of 5,708 people who have side effects when taking Differin from the FDA, and is updated regularly.

What is Differin?

Differin has active ingredients of adapalene. It is often used in acne. eHealthMe is studying from 5,740 Differin users. Check the latest studies of Differin.

What is Thin bones?

Thin bones is found to be associated with 2,439 drugs and 1,925 conditions by eHealthMe. Check the latest studies of Thin bones.

On Apr, 24, 2026

5,708 people reported to have side effects when taking Differin.
Among them, 23 people (0.4%) have Thin bones.

Among these 23 people:

What is the gender of people who have Thin bones when taking Differin? *

female: 95.45 %
male: 4.55 %

What is the age of people who have Thin bones when taking Differin? *

What are other drugs people take besides Differin? *

What are other side effects people have besides Thin bones? *

Osteopenia (a condition where bone mineral density is lower than normal): 20 people, 86.96%
Depression: 20 people, 86.96%
Anhedonia (inability to experience pleasure from activities usually found enjoyable): 19 people, 82.61%
Pain: 19 people, 82.61%
Stress And Anxiety: 19 people, 82.61%
Hypovolaemia (a decreased volume of circulating blood in the body): 18 people, 78.26%
Hepatitis (inflammation of the liver): 18 people, 78.26%
Fall: 18 people, 78.26%
Osteonecrosis Of Jaw (death of bone of jaw): 18 people, 78.26%
Osteomyelitis Chronic (long lasting infection of bone marrow): 18 people, 78.26%

What are the existing conditions these people have? *

Sinus Disorder (disease of sinus): 1 person, 4.35%
Hiv Infection: 1 person, 4.35%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 4.35%
Asthma: 1 person, 4.35%
Androgenetic Alopecia (common form of hair loss): 1 person, 4.35%
Adverse Event: 1 person, 4.35%
Acne Cystic (skin problems that cause pimples): 1 person, 4.35%

* Approximation only. Some reports may have incomplete information.

Do you take Differin and have Thin bones?

- Check whether Thin bones is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Differin:

Differin (5,740 reports)

Thin bones treatments and more:

Thin bones (290,733 reports)

Browse all side effects of Differin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Thin bones:

Thin bones (2,439 drugs)

Browse all the conditions that are associated with Thin bones:

Thin bones (1,925 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on adapalene (the active ingredients of Differin) and Differin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.