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Digoxin and Injection site irritation - a phase IV clinical study of FDA data

Summary:

Injection site irritation is reported as a side effect among people who take Digoxin (digoxin), especially for people who are female, 60+ old, also take Coumadin, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Injection site irritation when taking Digoxin. It is created by eHealthMe based on reports of 92,292 people who have side effects when taking Digoxin from the FDA, and is updated regularly.

What is Digoxin?

Digoxin has active ingredients of digoxin. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 93,740 Digoxin users. Check the latest studies of Digoxin.

What is Injection site irritation?

Injection site irritation is found to be associated with 452 drugs and 511 conditions by eHealthMe. Check the latest studies of Injection site irritation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

92,292 people reported to have side effects when taking Digoxin.
Among them, 15 people (0.02%) have Injection site irritation.

Could Digoxin cause Injection site irritation?

Among these 15 people:

What is the gender of people who have Injection site irritation when taking Digoxin? *

  • female: 80 %
  • male: 20 %

What is the age of people who have Injection site irritation when taking Digoxin? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 10 %
  • 50-59: 10 %
  • 60+: 80 %

What are other drugs people take besides Digoxin? *

  1. Humira: 5 people, 33.33%
  2. Furosemide: 5 people, 33.33%
  3. Coumadin: 5 people, 33.33%
  4. Lisinopril: 4 people, 26.67%
  5. Folic Acid: 3 people, 20.00%
  6. Forteo: 3 people, 20.00%
  7. Aspirin: 2 people, 13.33%
  8. Methotrexate: 2 people, 13.33%
  9. Avandia: 2 people, 13.33%
  10. Spironolactone And Hydrochlorothiazide: 2 people, 13.33%

What are other side effects people have besides Injection site irritation? *

  1. Weight Decreased: 3 people, 20.00%
  2. Pain In Extremity: 3 people, 20.00%
  3. Injection Site Erythema (redness at injection site): 2 people, 13.33%
  4. Nausea (feeling of having an urge to vomit): 2 people, 13.33%
  5. Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight): 2 people, 13.33%
  6. Injection Site Pain: 2 people, 13.33%
  7. Feeling Abnormal: 2 people, 13.33%
  8. Hypersensitivity: 1 person, 6.67%
  9. Headache (pain in head): 1 person, 6.67%
  10. Gout (uric acid crystals building up in the body): 1 person, 6.67%

What are the existing conditions these people have? *

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 26.67%
  2. Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 20.00%
  3. Osteoporosis (bones weak and more likely to break): 3 people, 20.00%
  4. Thyroid Diseases: 1 person, 6.67%
  5. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 6.67%
  6. Fluid Imbalance (imbalance of fluid in body in intake and fluid lost): 1 person, 6.67%
  7. Diabetes: 1 person, 6.67%
  8. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 6.67%
  9. Chronic Renal Failure (kidney failure): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Digoxin and have Injection site irritation?

- Check whether Injection site irritation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Digoxin:

Injection site irritation treatments and more:

How severe was Injection site irritation and when was it recovered:

Expand to all the drugs that have ingredients of digoxin:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Digoxin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Injection site irritation:

Browse all the conditions that are associated with Injection site irritation:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on digoxin (the active ingredients of Digoxin) and Digoxin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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