Diphen and Dactylitis - a phase IV clinical study of FDA data

Summary:

Dactylitis is reported as a side effect among people who take Diphen (diphenhydramine hydrochloride), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Acetaminophen, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Dactylitis when taking Diphen. It is created by eHealthMe based on reports of 113,958 people who have side effects when taking Diphen from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,430 Diphen users. Check the latest studies of Diphen.

What is Dactylitis?

Dactylitis (dactylitis or sausage digit is inflammation of an entire digit (a finger or toe), and can be painful) is found to be associated with 144 drugs and 179 conditions by eHealthMe. Check the latest studies of Dactylitis.

On Jan, 07, 2026

113,958 people reported to have side effects when taking Diphen.
Among them, 96 people (0.08%) have Dactylitis.

Among these 96 people:

* Approximation only. Some reports may have incomplete information.

Do you take Diphen and have Dactylitis?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Diphen:

Diphen (115,430 reports)

Dactylitis treatments and more:

Dactylitis (1,222 reports)

How severe was Dactylitis and when was it recovered:

Dactylitis in Diphen

Expand to all the drugs that have ingredients of diphenhydramine hydrochloride:

Dactylitis and drugs with ingredients of diphenhydramine hydrochloride (38 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Diphen side effects:

Browse all side effects of Diphen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Dactylitis:

Browse all the drugs that are associated with Dactylitis:

Dactylitis (144 drugs)

Common conditions associated with Dactylitis:

Psoriatic arthropathy: 497 reports
Psoriasis: 169 reports
Ankylosing spondylitis: 103 reports

Browse all the conditions that are associated with Dactylitis:

Dactylitis (179 conditions)

Drugs similar to Diphen and Dactylitis :

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride (the active ingredients of Diphen) and Diphen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.