Diphen and Exercise tolerance decreased - a phase IV clinical study of FDA data

Summary:

Exercise tolerance decreased is reported as a side effect among people who take Diphen (diphenhydramine hydrochloride), especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months also take Pantoprazole, and have Polyarthritis.

The phase IV clinical study analyzes which people have Exercise tolerance decreased when taking Diphen. It is created by eHealthMe based on reports of 113,958 people who have side effects when taking Diphen from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

What is Exercise tolerance decreased?

Exercise tolerance decreased is found to be associated with 622 drugs and 727 conditions by eHealthMe. Check the latest studies of Exercise tolerance decreased.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

113,958 people reported to have side effects when taking Diphen.
Among them, 26 people (0.02%) have Exercise tolerance decreased.

Could Diphen cause Exercise tolerance decreased?

Among these 26 people:

How long have people been on Diphen when they have Exercise tolerance decreased? *

What is the gender of people who have Exercise tolerance decreased when taking Diphen? *

female: 50 %
male: 50 %

What is the age of people who have Exercise tolerance decreased when taking Diphen? *

What are other drugs people take besides Diphen? *

What are other side effects people have besides Exercise tolerance decreased? *

High Blood Pressure: 15 people, 57.69%
Pain: 14 people, 53.85%
Fatigue (feeling of tiredness): 13 people, 50.00%
Cough: 12 people, 46.15%
Joint Pain: 12 people, 46.15%
Dyspnea (difficult or laboured breathing): 11 people, 42.31%
Headache (pain in head): 11 people, 42.31%
Joint Swelling: 10 people, 38.46%
Fall: 9 people, 34.62%
Heart Rate Decreased: 9 people, 34.62%

What are the existing conditions these people have? *

Polymyositis (inflammatory muscle disease that causes weakness of the skeletal muscles): 7 people, 26.92%
Polyarthritis (arthritis which involves 5 or more joints simultaneously): 7 people, 26.92%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 15.38%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 4 people, 15.38%
Myositis (inflammation of the muscles): 4 people, 15.38%
Hiv Infection: 4 people, 15.38%
Antisynthetase Syndrome (chronic autoimmune disease of unknown cause): 3 people, 11.54%
Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer): 3 people, 11.54%
Periorbital Oedema (swelling around the eyes): 3 people, 11.54%
Folliculitis (infection of hair root): 3 people, 11.54%

* Approximation only. Some reports may have incomplete information.

Do you take Diphen and have Exercise tolerance decreased?

- Check whether Exercise tolerance decreased is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Diphen:

Diphen (115,432 reports)

Browse all side effects of Diphen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Exercise tolerance decreased:

Exercise tolerance decreased (622 drugs)

Browse all the conditions that are associated with Exercise tolerance decreased:

Exercise tolerance decreased (727 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride (the active ingredients of Diphen) and Diphen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.