Diphen and Keratoconjunctivitis sicca - a phase IV clinical study of FDA data

Summary:

We study 117,041 people who take Diphen (diphenhydramine hydrochloride) or have Keratoconjunctivitis sicca. No report of Keratoconjunctivitis sicca is found in people who take Diphen.

The phase IV clinical study is created by eHealthMe based on reports from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,430 Diphen users. Check the latest studies of Diphen.

What is Keratoconjunctivitis Sicca?

Keratoconjunctivitis sicca (inflammation of the conjunctiva and cornea of the eye with decreased tears) is found to be associated with 355 drugs and 693 conditions by eHealthMe. Check the latest studies of Keratoconjunctivitis sicca.

On Jan, 21, 2026

No report is found.

Do you take Diphen and have Keratoconjunctivitis sicca?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Diphen:

Diphen (115,430 reports)

Browse all side effects of Diphen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Keratoconjunctivitis sicca:

Keratoconjunctivitis sicca

Browse all the conditions that are associated with Keratoconjunctivitis sicca:

Keratoconjunctivitis sicca

Drugs similar to Diphen and Keratoconjunctivitis sicca :

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride (the active ingredients of Diphen) and Diphen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.