Diphen and Vocal cord disorder - a phase IV clinical study of FDA data

Summary:

Vocal cord disorder is reported as a side effect among people who take Diphen (diphenhydramine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Acetaminophen, and have Immunodeficiency common variable.

The phase IV clinical study analyzes which people have Vocal cord disorder when taking Diphen. It is created by eHealthMe based on reports of 113,958 people who have side effects when taking Diphen from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

What is Vocal cord disorder?

Vocal cord disorder is found to be associated with 337 drugs and 443 conditions by eHealthMe. Check the latest studies of Vocal cord disorder.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

113,958 people reported to have side effects when taking Diphen.
Among them, 37 people (0.03%) have Vocal cord disorder.

Among these 37 people:

How long have people been on Diphen when they have Vocal cord disorder? *

What is the gender of people who have Vocal cord disorder when taking Diphen? *

female: 83.78 %
male: 16.22 %

What is the age of people who have Vocal cord disorder when taking Diphen? *

What are other drugs people take besides Diphen? *

What are other side effects people have besides Vocal cord disorder? *

Fatigue (feeling of tiredness): 15 people, 40.54%
Headache (pain in head): 13 people, 35.14%
Nasopharyngitis (inflammation of the nasopharynx): 11 people, 29.73%
Asthma: 11 people, 29.73%
Pharyngitis (inflammation of the pharynx, causing a sore throat): 11 people, 29.73%
Respiratory Tract Infection: 11 people, 29.73%
Cardiac Disorder: 9 people, 24.32%
Lower Respiratory Tract Infection: 9 people, 24.32%
Weight Increased: 8 people, 21.62%
Sinusitis (inflammation of sinus): 7 people, 18.92%

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 17 people, 45.95%
Asthma: 8 people, 21.62%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 10.81%
Rhinorrhea (watery mucus discharge from the nose): 2 people, 5.41%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 2 people, 5.41%
Constipation: 2 people, 5.41%
Gastric Ulcer (stomach ulcer): 2 people, 5.41%
High Blood Pressure: 2 people, 5.41%
Hypokalemia (low potassium): 2 people, 5.41%
Immunodeficiency: 2 people, 5.41%

* Approximation only. Some reports may have incomplete information.

Do you take Diphen and have Vocal cord disorder?

- Check whether Vocal cord disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Diphen:

Diphen (115,432 reports)

Browse all side effects of Diphen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Vocal cord disorder:

Vocal cord disorder (337 drugs)

Browse all the conditions that are associated with Vocal cord disorder:

Vocal cord disorder (443 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride (the active ingredients of Diphen) and Diphen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.