Diphen and Volvulus - a phase IV clinical study of FDA data

Summary:

Volvulus is reported as a side effect among people who take Diphen (diphenhydramine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Dexamethasone, and have Immunodeficiency common variable.

The phase IV clinical study analyzes which people have Volvulus when taking Diphen. It is created by eHealthMe based on reports of 113,958 people who have side effects when taking Diphen from the FDA, and is updated regularly.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

What is Volvulus?

Volvulus (obstruction caused by twisting of the stomach or intestine) is found to be associated with 277 drugs and 377 conditions by eHealthMe. Check the latest studies of Volvulus.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

113,958 people reported to have side effects when taking Diphen.
Among them, 21 people (0.02%) have Volvulus.

Among these 21 people:

How long have people been on Diphen when they have Volvulus? *

What is the gender of people who have Volvulus when taking Diphen? *

female: 100 %
male: 0.0 %

What is the age of people who have Volvulus when taking Diphen? *

What are other drugs people take besides Diphen? *

What are other side effects people have besides Volvulus? *

Pneumonia: 14 people, 66.67%
Intestinal Obstruction: 10 people, 47.62%
Sepsis (a severe blood infection that can lead to organ failure and death): 9 people, 42.86%
Ileus Paralytic (obstruction of the intestine due to paralysis of the intestinal muscles): 9 people, 42.86%
Fall: 5 people, 23.81%
Fever: 4 people, 19.05%
Stress And Anxiety: 4 people, 19.05%
Common Peroneal Nerve Dysfunction (dysfunction of nerve controlling movement and sensation to the lower leg, foot and toes): 4 people, 19.05%
Weight Decreased: 4 people, 19.05%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 19.05%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 19.05%
Inflammation: 4 people, 19.05%
Immunodeficiency Common Variable: 4 people, 19.05%
Immunodeficiency: 3 people, 14.29%
Systemic Sclerosis (Scleroderma) (an autoimmune or connective tissue disease. it is characterized by thickening of the skin): 2 people, 9.52%
Sepsis (a severe blood infection that can lead to organ failure and death): 2 people, 9.52%
Pneumonia: 2 people, 9.52%
Interstitial Lung Disease: 2 people, 9.52%
Ileus Paralytic (obstruction of the intestine due to paralysis of the intestinal muscles): 2 people, 9.52%
Vasculitis (inflammation of a blood vessel or blood vessels): 1 person, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Diphen and have Volvulus?

- Check whether Volvulus is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Diphen:

Diphen (115,432 reports)

Volvulus treatments and more:

Volvulus (2,613 reports)

Browse all side effects of Diphen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Volvulus:

Volvulus (277 drugs)

Browse all the conditions that are associated with Volvulus:

Volvulus (377 conditions)

Related publications that referenced our studies

Amit K J Mandal, Umar F Khan, Constantinos G Missouris, "Ventricular tachycardia in a patient with sigmoid volvulus on treatment with donepezil", Clinical Toxicology, 2019 Jan .
Amit K J Mandal, Umar F Khan, Constantinos G Missouris, "Ventricular tachycardia in a patient with sigmoid volvulus on treatment with donepezil", Clinical Toxicology, 2019 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride (the active ingredients of Diphen) and Diphen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.