Diphenhydramine hydrochloride and Abnormal behavior - a phase IV clinical study of FDA data

Summary:

Abnormal behavior is reported as a side effect among people who take Diphenhydramine hydrochloride (diphenhydramine hydrochloride), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Metformin, and have Diabetes.

The phase IV clinical study analyzes which people have Abnormal behavior when taking Diphenhydramine hydrochloride. It is created by eHealthMe based on reports of 24,692 people who have side effects when taking Diphenhydramine hydrochloride from the FDA, and is updated regularly.

What is Diphenhydramine hydrochloride?

Diphenhydramine hydrochloride has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 26,097 Diphenhydramine hydrochloride users. Check the latest studies of Diphenhydramine hydrochloride.

What is Abnormal behavior?

Abnormal behavior is found to be associated with 1,358 drugs and 1,957 conditions by eHealthMe. Check the latest studies of Abnormal behavior.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

24,692 people reported to have side effects when taking Diphenhydramine hydrochloride.
Among them, 41 people (0.17%) have Abnormal behavior.

Could Diphenhydramine hydrochloride cause Abnormal behavior?

Among these 41 people:

How long have people been on Diphenhydramine hydrochloride when they have Abnormal behavior? *

What is the gender of people who have Abnormal behavior when taking Diphenhydramine hydrochloride? *

female: 69.44 %
male: 30.56 %

What is the age of people who have Abnormal behavior when taking Diphenhydramine hydrochloride? *

What are other drugs people take besides Diphenhydramine hydrochloride? *

What are other side effects people have besides Abnormal behavior? *

Agitation (state of anxiety or nervous excitement): 27 people, 65.85%
Depression: 21 people, 51.22%
Fatigue (feeling of tiredness): 16 people, 39.02%
Dyspnea (difficult or laboured breathing): 15 people, 36.59%
Drowsiness: 14 people, 34.15%
Aggression: 14 people, 34.15%
Memory Loss: 14 people, 34.15%
Blood Glucose Decreased: 14 people, 34.15%
Nervousness: 14 people, 34.15%
The Flu (the flu is caused by an influenza virus): 14 people, 34.15%

What are the existing conditions these people have? *

Diabetes: 14 people, 34.15%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 13 people, 31.71%
High Blood Pressure: 13 people, 31.71%
Depression: 9 people, 21.95%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 4.88%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 2 people, 4.88%
Pain: 2 people, 4.88%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 4.88%
Seasonal Allergy (allergic condition due to certain season): 2 people, 4.88%
Emotional Disorder: 1 person, 2.44%

* Approximation only. Some reports may have incomplete information.

Do you take Diphenhydramine hydrochloride and have Abnormal behavior?

- Check whether Abnormal behavior is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Diphenhydramine hydrochloride:

Diphenhydramine hydrochloride (26,097 reports)

Browse all side effects of Diphenhydramine hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Abnormal behavior:

Abnormal behavior (1,358 drugs)

Browse all the conditions that are associated with Abnormal behavior:

Abnormal behavior (1,957 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride (the active ingredients of Diphenhydramine hydrochloride) and Diphenhydramine hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.