Diphenhydramine hydrochloride and Polyp - a phase IV clinical study of FDA data

Summary:

Polyp is reported as a side effect among people who take Diphenhydramine hydrochloride (diphenhydramine hydrochloride), especially for people who are female, 60+ old, also take Acetaminophen, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Polyp when taking Diphenhydramine hydrochloride. It is created by eHealthMe based on reports of 24,692 people who have side effects when taking Diphenhydramine hydrochloride from the FDA, and is updated regularly.

What is Diphenhydramine hydrochloride?

Diphenhydramine hydrochloride has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 26,097 Diphenhydramine hydrochloride users. Check the latest studies of Diphenhydramine hydrochloride.

What is Polyp?

Polyp is found to be associated with 797 drugs and 777 conditions by eHealthMe. Check the latest studies of Polyp.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 18, 2026

24,692 people reported to have side effects when taking Diphenhydramine hydrochloride.
Among them, 40 people (0.16%) have Polyp.

Could Diphenhydramine hydrochloride cause Polyp?

Among these 40 people:

What is the gender of people who have Polyp when taking Diphenhydramine hydrochloride? *

female: 80.95 %
male: 19.05 %

What is the age of people who have Polyp when taking Diphenhydramine hydrochloride? *

What are other drugs people take besides Diphenhydramine hydrochloride? *

What are other side effects people have besides Polyp? *

High Blood Pressure: 22 people, 55.00%
Fatigue (feeling of tiredness): 21 people, 52.50%
Blood Pressure Diastolic Abnormal: 19 people, 47.50%
Abdominal Pain: 17 people, 42.50%
Blood Pressure Fluctuation: 17 people, 42.50%
Sinusitis (inflammation of sinus): 15 people, 37.50%
Heart Rate Decreased: 14 people, 35.00%
Nasopharyngitis (inflammation of the nasopharynx): 13 people, 32.50%
Oedema Peripheral (superficial swelling): 12 people, 30.00%
Joint Pain: 12 people, 30.00%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 24 people, 60.00%
Immunodeficiency Common Variable: 5 people, 12.50%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 10.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 10.00%
Arrhythmias (irregular heartbeat): 3 people, 7.50%
Immunodeficiency: 2 people, 5.00%
Immune System Disorder: 2 people, 5.00%
Hypergammaglobulinaemia (elevated levels of gamma globulin): 2 people, 5.00%
Colon Cancer: 2 people, 5.00%
Antisynthetase Syndrome (chronic autoimmune disease of unknown cause): 2 people, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Diphenhydramine hydrochloride and have Polyp?

- Check whether Polyp is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Diphenhydramine hydrochloride:

Diphenhydramine hydrochloride (26,097 reports)

Polyp treatments and more:

Polyp (9,393 reports)

Browse all side effects of Diphenhydramine hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Polyp:

Polyp (797 drugs)

Browse all the conditions that are associated with Polyp:

Polyp (777 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride (the active ingredients of Diphenhydramine hydrochloride) and Diphenhydramine hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.