Diphenhydramine hydrochloride and Type 2 diabetes - a phase IV clinical study of FDA data

Summary:

Type 2 diabetes is reported as a side effect among people who take Diphenhydramine hydrochloride (diphenhydramine hydrochloride), especially for people who are female, 50-59 old, have been taking the drug for 1 - 6 months also take Acetaminophen, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Type 2 diabetes when taking Diphenhydramine hydrochloride. It is created by eHealthMe based on reports of 24,692 people who have side effects when taking Diphenhydramine hydrochloride from the FDA, and is updated regularly.

What is Diphenhydramine hydrochloride?

Diphenhydramine hydrochloride has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 26,097 Diphenhydramine hydrochloride users. Check the latest studies of Diphenhydramine hydrochloride.

What is Type 2 diabetes?

Type 2 diabetes is found to be associated with 1,432 drugs and 2,345 conditions by eHealthMe. Check the latest studies of Type 2 diabetes.

On Jul, 10, 2026

24,692 people reported to have side effects when taking Diphenhydramine hydrochloride.
Among them, 438 people (1.77%) have Type 2 diabetes.

Could Diphenhydramine hydrochloride cause Type 2 diabetes?

Among these 438 people:

How long have people been on Diphenhydramine hydrochloride when they have Type 2 diabetes? *

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What is the gender of people who have Type 2 diabetes when taking Diphenhydramine hydrochloride? *

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What is the age of people who have Type 2 diabetes when taking Diphenhydramine hydrochloride? *

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* Approximation only. Some reports may have incomplete information.

Do you take Diphenhydramine hydrochloride and have Type 2 diabetes?

- Check whether Type 2 diabetes is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Diphenhydramine hydrochloride:

Diphenhydramine hydrochloride (26,097 reports)

Type 2 diabetes treatments and more:

Type 2 diabetes (391,582 reports)

How severe was Type 2 diabetes and when was it recovered:

Type 2 diabetes in Diphenhydramine hydrochloride

Expand to all the drugs that have ingredients of diphenhydramine hydrochloride:

Type 2 diabetes and drugs with ingredients of diphenhydramine hydrochloride (1,053 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Diphenhydramine hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Type 2 diabetes:

Type 2 diabetes (1,432 drugs)

Browse all the conditions that are associated with Type 2 diabetes:

Type 2 diabetes (2,345 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on diphenhydramine hydrochloride (the active ingredients of Diphenhydramine hydrochloride) and Diphenhydramine hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.