Ditropan and Knee joint replacement - a phase IV clinical study of FDA data

Summary:

Knee joint replacement is reported as a side effect among people who take Ditropan (oxybutynin chloride), especially for people who are female, 60+ old, also take Synthroid, and have Osteoporosis.

The phase IV clinical study analyzes which people have Knee joint replacement when taking Ditropan. It is created by eHealthMe based on reports of 11,571 people who have side effects when taking Ditropan from the FDA, and is updated regularly.

What is Ditropan?

Ditropan has active ingredients of oxybutynin chloride. It is often used in urge incontinence. eHealthMe is studying from 11,799 Ditropan users. Check the latest studies of Ditropan.

What is Knee joint replacement?

Knee joint replacement is found to be associated with 953 drugs and 1,228 conditions by eHealthMe. Check the latest studies of Knee joint replacement.

On Jul, 09, 2026

11,571 people reported to have side effects when taking Ditropan.
Among them, 32 people (0.28%) have Knee joint replacement.

Could Ditropan cause Knee joint replacement?

Among these 32 people:

What is the gender of people who have Knee joint replacement when taking Ditropan? *

female: 84.38 %
male: 15.62 %

What is the age of people who have Knee joint replacement when taking Ditropan? *

What are other drugs people take besides Ditropan? *

What are other side effects people have besides Knee joint replacement? *

Fall: 11 people, 34.38%
Pain: 7 people, 21.88%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 6 people, 18.75%
Weakness: 6 people, 18.75%
Head Injury: 6 people, 18.75%
Femur Fracture: 6 people, 18.75%
Diarrhea: 5 people, 15.62%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 5 people, 15.62%
Gait Disturbance: 5 people, 15.62%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 5 people, 15.62%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 7 people, 21.88%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 18.75%
Pain: 5 people, 15.62%
Cardiac Disorder: 5 people, 15.62%
Fluid Retention (an abnormal accumulation of fluid in the blood): 4 people, 12.50%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 9.38%
Erection Problems: 3 people, 9.38%
Gout (uric acid crystals building up in the body): 3 people, 9.38%
Gastric Disorder (disease of stomach): 3 people, 9.38%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 3 people, 9.38%

* Approximation only. Some reports may have incomplete information.

Do you take Ditropan and have Knee joint replacement?

- Check whether Knee joint replacement is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ditropan:

Ditropan (11,799 reports)

Browse all side effects of Ditropan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Knee joint replacement:

Knee joint replacement (953 drugs)

Browse all the conditions that are associated with Knee joint replacement:

Knee joint replacement (1,228 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on oxybutynin chloride (the active ingredients of Ditropan) and Ditropan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.