Divalproex sodium and Acute hepatic failure - a phase IV clinical study of FDA data

Summary:

Acute hepatic failure is reported as a side effect among people who take Divalproex sodium (divalproex sodium), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Clonazepam, and have Seizures.

The phase IV clinical study analyzes which people have Acute hepatic failure when taking Divalproex sodium. It is created by eHealthMe based on reports of 9,295 people who have side effects when taking Divalproex sodium from the FDA, and is updated regularly.

What is Divalproex sodium?

Divalproex sodium has active ingredients of divalproex sodium. It is often used in epilepsy. eHealthMe is studying from 9,483 Divalproex sodium users. Check the latest studies of Divalproex sodium.

What is Acute hepatic failure?

Acute hepatic failure is found to be associated with 710 drugs and 1,185 conditions by eHealthMe. Check the latest studies of Acute hepatic failure.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 19, 2026

9,295 people reported to have side effects when taking Divalproex sodium.
Among them, 34 people (0.37%) have Acute hepatic failure.

Could Divalproex sodium cause Acute hepatic failure?

Among these 34 people:

How long have people been on Divalproex sodium when they have Acute hepatic failure? *

What is the gender of people who have Acute hepatic failure when taking Divalproex sodium? *

female: 61.76 %
male: 38.24 %

What is the age of people who have Acute hepatic failure when taking Divalproex sodium? *

What are other drugs people take besides Divalproex sodium? *

What are other side effects people have besides Acute hepatic failure? *

Hepatic Encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure): 8 people, 23.53%
Drug-Induced Liver Injury (diseases of the liver that are caused by physician-prescribed medications): 5 people, 14.71%
Acute Respiratory Failure: 4 people, 11.76%
Septic Shock (shock due to blood infection): 4 people, 11.76%
Hepatotoxicity (chemical-driven liver damage): 4 people, 11.76%
Anaemia Macrocytic (a macrocytic class of anaemia): 3 people, 8.82%
Cardio-Respiratory Arrest (sudden dysfunction of heart and lungs): 3 people, 8.82%
International Normalised Ratio Increased: 3 people, 8.82%
Brain Oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain): 3 people, 8.82%
Cross Sensitivity Reaction: 3 people, 8.82%

What are the existing conditions these people have? *

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 10 people, 29.41%
Trigeminal Neuralgia (a painful condition of the nerve responsible for most facial sensation): 5 people, 14.71%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 4 people, 11.76%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 2 people, 5.88%
High Blood Pressure: 2 people, 5.88%
Type 2 Diabetes: 1 person, 2.94%
Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 1 person, 2.94%
Obsessive-Compulsive Disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;): 1 person, 2.94%
Myoclonic Epilepsy (type of epilepsy with quick little jerks of the arms, shoulder, or occasionally the legs): 1 person, 2.94%
Ischaemic Cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease): 1 person, 2.94%

* Approximation only. Some reports may have incomplete information.

Do you take Divalproex sodium and have Acute hepatic failure?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Divalproex sodium:

Divalproex sodium (9,483 reports)

Browse all side effects of Divalproex sodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Acute hepatic failure:

Acute hepatic failure (710 drugs)

Browse all the conditions that are associated with Acute hepatic failure:

Acute hepatic failure (1,185 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on divalproex sodium (the active ingredients of Divalproex sodium) and Divalproex sodium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.