Divigel and Fatigue - a phase IV clinical study of FDA data

Summary:

Fatigue is reported as a side effect among people who take Divigel (estradiol), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Orencia, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Fatigue when taking Divigel. It is created by eHealthMe based on reports of 840 people who have side effects when taking Divigel from the FDA, and is updated regularly.

What is Divigel?

Divigel has active ingredients of estradiol. It is often used in menopause. eHealthMe is studying from 894 Divigel users. Check the latest studies of Divigel.

What is Fatigue?

Fatigue (feeling of tiredness) is found to be associated with 4,027 drugs and 6,379 conditions by eHealthMe. Check the latest studies of Fatigue.

On Jul, 09, 2026

840 people reported to have side effects when taking Divigel.
Among them, 42 people (5.0%) have Fatigue.

Among these 42 people:

How long have people been on Divigel when they have Fatigue? *

What is the gender of people who have Fatigue when taking Divigel? *

female: 100 %
male: 0.0 %

What is the age of people who have Fatigue when taking Divigel? *

What are other drugs people take besides Divigel? *

What are other side effects people have besides Fatigue? *

Weakness: 13 people, 30.95%
Joint Pain: 12 people, 28.57%
Chest Pain: 10 people, 23.81%
Oropharyngeal Pain: 9 people, 21.43%
Nausea (feeling of having an urge to vomit): 9 people, 21.43%
Headache (pain in head): 8 people, 19.05%
Fungal Infection: 8 people, 19.05%
Fever: 7 people, 16.67%
Gait Disturbance: 6 people, 14.29%
Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 6 people, 14.29%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 19.05%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 11.90%
Ankylosing Spondylitis (type of arthritis affecting the spine): 3 people, 7.14%
Nervousness: 3 people, 7.14%
Arrhythmias (irregular heartbeat): 2 people, 4.76%
Immune System Disorder: 2 people, 4.76%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 4.76%
Hypersensitivity: 2 people, 4.76%
Hypergammaglobulinaemia (elevated levels of gamma globulin): 2 people, 4.76%
Blood Testosterone Decreased: 2 people, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Divigel and have Fatigue?

- Check whether Fatigue is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Divigel:

Divigel (894 reports)

Fatigue treatments and more:

Fatigue (967,537 reports)

Browse all side effects of Divigel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Fatigue:

Fatigue (4,027 drugs)

Browse all the conditions that are associated with Fatigue:

Fatigue (6,379 conditions)

Related publications that referenced our studies

Peel MM, Cooke M, Lewis-Peel HJ, Lea RA, Moyle W, "A randomized controlled trial of coenzyme Q 10 for fatigue in the late-onset sequelae of poliomyelitis", Complementary therapies in medicine, 2015 Dec .
Peel MM, Cooke M, Lewis-Peel HJ, Lea RA, Moyle W, "A randomized controlled trial of coenzyme Q 10 for fatigue in the late-onset sequelae of poliomyelitis", Complementary therapies in medicine, 2015 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on estradiol (the active ingredients of Divigel) and Divigel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.