Donepezil hydrochloride and Multiple sclerosis - a phase IV clinical study of FDA data

Summary:

Multiple sclerosis is reported as a side effect among people who take Donepezil hydrochloride (donepezil hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Lisinopril, and have Muscle spasms.

The phase IV clinical study analyzes which people have Multiple sclerosis when taking Donepezil hydrochloride. It is created by eHealthMe based on reports of 4,214 people who have side effects when taking Donepezil hydrochloride from the FDA, and is updated regularly.

What is Donepezil hydrochloride?

Donepezil hydrochloride has active ingredients of donepezil hydrochloride. It is often used in dementia. eHealthMe is studying from 4,263 Donepezil hydrochloride users. Check the latest studies of Donepezil hydrochloride.

What is Multiple sclerosis?

Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath) is found to be associated with 1,085 drugs and 1,365 conditions by eHealthMe. Check the latest studies of Multiple sclerosis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

4,214 people reported to have side effects when taking Donepezil hydrochloride.
Among them, 13 people (0.31%) have Multiple sclerosis.

Could Donepezil hydrochloride cause Multiple sclerosis?

Among these 13 people:

How long have people been on Donepezil hydrochloride when they have Multiple sclerosis? *

What is the gender of people who have Multiple sclerosis when taking Donepezil hydrochloride? *

female: 69.23 %
male: 30.77 %

What is the age of people who have Multiple sclerosis when taking Donepezil hydrochloride? *

What are other drugs people take besides Donepezil hydrochloride? *

What are other side effects people have besides Multiple sclerosis? *

Nausea (feeling of having an urge to vomit): 4 people, 30.77%
White Blood Cell Count Decreased: 3 people, 23.08%
Gastric Disorder (disease of stomach): 3 people, 23.08%
Memory Loss: 3 people, 23.08%
Diarrhea: 3 people, 23.08%
Lyme Disease (a bacterial infection that is spread to humans by infected ticks): 2 people, 15.38%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 2 people, 15.38%
Fall: 2 people, 15.38%
Muscle Spasms (muscle contraction): 2 people, 15.38%
Bone Pain: 2 people, 15.38%

What are the existing conditions these people have? *

Depression: 3 people, 23.08%
Pain: 3 people, 23.08%
High Blood Pressure: 3 people, 23.08%
Memory Loss: 3 people, 23.08%
Muscle Spasms (muscle contraction): 3 people, 23.08%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 2 people, 15.38%
Nausea (feeling of having an urge to vomit): 2 people, 15.38%
Erosive Oesophagitis (acid reflux disease can cause tissue damage in the oesophagus over time): 2 people, 15.38%
Fatigue (feeling of tiredness): 2 people, 15.38%
Demyelination (loss of the myelin covering of some nerve fibres resulting in their impaired function): 2 people, 15.38%

* Approximation only. Some reports may have incomplete information.

Do you take Donepezil hydrochloride and have Multiple sclerosis?

- Check whether Multiple sclerosis is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Donepezil hydrochloride:

Donepezil hydrochloride (4,263 reports)

Browse all side effects of Donepezil hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Multiple sclerosis:

Multiple sclerosis (1,085 drugs)

Browse all the conditions that are associated with Multiple sclerosis:

Multiple sclerosis (1,365 conditions)

Related publications that referenced our studies

Christopher KL, Elner VM, Demirci H, "Conjunctival Lymphoma in a Patient on Fingolimod for Relapsing-Remitting Multiple Sclerosis", Ophthalmic Plastic & Reconstructive Surgery, 2017 May .
Christopher, K. L., Elner, V. M., & Demirci, H. , "Conjunctival lymphoma in a patient on fingolimod for relapsing-remitting multiple sclerosis", Ophthalmic plastic and reconstructive surgery , 2014 Jan .
Christopher KL, Elner VM, Demirci H, "Conjunctival Lymphoma in a Patient on Fingolimod for Relapsing-Remitting Multiple Sclerosis", Ophthalmic Plastic & Reconstructive Surgery, 2017 May .
Christopher, K. L., Elner, V. M., & Demirci, H. , "Conjunctival lymphoma in a patient on fingolimod for relapsing-remitting multiple sclerosis", Ophthalmic plastic and reconstructive surgery , 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on donepezil hydrochloride (the active ingredients of Donepezil hydrochloride) and Donepezil hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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