Donepezil and Diabetes - a phase IV clinical study of FDA data

Summary:

Diabetes is reported as a side effect among people who take Donepezil (donepezil hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Vitamin D3, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Diabetes when taking Donepezil. It is created by eHealthMe based on reports of 24,262 people who have side effects when taking Donepezil from the FDA, and is updated regularly.

What is Donepezil?

Donepezil has active ingredients of donepezil hydrochloride. It is often used in dementia. eHealthMe is studying from 24,564 Donepezil users. Check the latest studies of Donepezil.

What is Diabetes?

Diabetes is found to be associated with 2,010 drugs and 2,855 conditions by eHealthMe. Check the latest studies of Diabetes.



On Jul, 09, 2026

24,262 people reported to have side effects when taking Donepezil.
Among them, 66 people (0.27%) have Diabetes.

Could Donepezil cause Diabetes?

Among these 66 people:

How long have people been on Donepezil when they have Diabetes? *

  • < 1 month: 50 %
  • 1 - 6 months: 50 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Diabetes when taking Donepezil? *

  • female: 51.61 %
  • male: 48.39 %

What is the age of people who have Diabetes when taking Donepezil? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 2.33 %
  • 40-49: 4.65 %
  • 50-59: 9.3 %
  • 60+: 83.72 %

What are other drugs people take besides Donepezil? *

  1. Vitamin D3: 14 people, 21.21%
  2. Metformin: 10 people, 15.15%
  3. Vitamin B12: 10 people, 15.15%
  4. Amlodipine: 9 people, 13.64%
  5. Lisinopril: 8 people, 12.12%
  6. Prednisone: 7 people, 10.61%
  7. Nexium: 7 people, 10.61%
  8. Vitamin B: 6 people, 9.09%
  9. Eszopiclone: 6 people, 9.09%
  10. Melatonin: 6 people, 9.09%

What are other side effects people have besides Diabetes? *

  1. High Blood Pressure: 12 people, 18.18%
  2. Fall: 8 people, 12.12%
  3. Acute Kidney Failure: 7 people, 10.61%
  4. Pain: 7 people, 10.61%
  5. Fatigue (feeling of tiredness): 7 people, 10.61%
  6. Weakness: 7 people, 10.61%
  7. Nausea (feeling of having an urge to vomit): 7 people, 10.61%
  8. Nausea And Vomiting: 7 people, 10.61%
  9. Depression: 6 people, 9.09%
  10. Malaise (a feeling of general discomfort or uneasiness): 6 people, 9.09%

What are the existing conditions these people have? *

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 12.12%
  2. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 8 people, 12.12%
  3. Depression: 7 people, 10.61%
  4. Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 7 people, 10.61%
  5. High Blood Pressure: 6 people, 9.09%
  6. Immunodeficiency Common Variable: 5 people, 7.58%
  7. High Blood Cholesterol: 5 people, 7.58%
  8. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 7.58%
  9. Psychotic Disorder: 4 people, 6.06%
  10. Bipolar Disorder (mood disorder): 3 people, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Donepezil and have Diabetes?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Donepezil:

Diabetes treatments and more:

How severe was Diabetes and when was it recovered:

Expand to all the drugs that have ingredients of donepezil hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Donepezil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Diabetes:

Browse all the conditions that are associated with Diabetes:


How the study uses the data?

The study uses data from the FDA. It is based on donepezil hydrochloride (the active ingredients of Donepezil) and Donepezil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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