Donepezil and Hypercalcaemia - a phase IV clinical study of FDA data

Summary:

Hypercalcaemia is reported as a side effect among people who take Donepezil (donepezil hydrochloride), especially for people who are male, 60+ old, also take Aspirin, and have Osteoporosis.

The phase IV clinical study analyzes which people have Hypercalcaemia when taking Donepezil. It is created by eHealthMe based on reports of 24,262 people who have side effects when taking Donepezil from the FDA, and is updated regularly.

What is Donepezil?

Donepezil has active ingredients of donepezil hydrochloride. It is often used in dementia. eHealthMe is studying from 24,564 Donepezil users. Check the latest studies of Donepezil.

What is Hypercalcaemia?

Hypercalcaemia (elevated calcium (ca+) level in the blood) is found to be associated with 1,054 drugs and 1,018 conditions by eHealthMe. Check the latest studies of Hypercalcaemia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

24,262 people reported to have side effects when taking Donepezil.
Among them, 19 people (0.08%) have Hypercalcaemia.

Among these 19 people:

What is the gender of people who have Hypercalcaemia when taking Donepezil? *

female: 47.37 %
male: 52.63 %

What is the age of people who have Hypercalcaemia when taking Donepezil? *

What are other drugs people take besides Donepezil? *

Aspirin: 9 people, 47.37%
Lovenox: 7 people, 36.84%
Velcade: 7 people, 36.84%
Zometa: 6 people, 31.58%
Namenda: 6 people, 31.58%
Morphine Sulfate: 6 people, 31.58%
Celexa: 6 people, 31.58%
Melphalan Hydrochloride: 6 people, 31.58%
Coumadin: 6 people, 31.58%
Decadron: 6 people, 31.58%

What are other side effects people have besides Hypercalcaemia? *

Fatigue (feeling of tiredness): 8 people, 42.11%
Cardiac Arrest: 7 people, 36.84%
Visual Field Defect: 6 people, 31.58%
Stress And Anxiety: 6 people, 31.58%
Pneumonia: 6 people, 31.58%
Nausea (feeling of having an urge to vomit): 6 people, 31.58%
Basal Cell Carcinoma (a skin cancer, it rarely metastasizes or kills): 6 people, 31.58%
Muscle Aches (muscle pain): 6 people, 31.58%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 6 people, 31.58%
Pain: 6 people, 31.58%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 4 people, 21.05%
Constipation: 3 people, 15.79%
High Blood Pressure: 2 people, 10.53%
Pernicious Anaemia (anaemia due to lack of vitamin b12): 2 people, 10.53%
Parkinson's Disease: 2 people, 10.53%
Breast Cancer Female: 2 people, 10.53%
Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 2 people, 10.53%
Itching: 2 people, 10.53%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 10.53%
Gastritis (inflammation of stomach): 2 people, 10.53%

* Approximation only. Some reports may have incomplete information.

Do you take Donepezil and have Hypercalcaemia?

- Check whether Hypercalcaemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Donepezil:

Donepezil (24,564 reports)

Hypercalcaemia treatments and more:

Hypercalcaemia (18,731 reports)

Browse all side effects of Donepezil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypercalcaemia:

Hypercalcaemia (1,054 drugs)

Browse all the conditions that are associated with Hypercalcaemia:

Hypercalcaemia (1,018 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on donepezil hydrochloride (the active ingredients of Donepezil) and Donepezil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.