Donepezil and Hypertonic bladder - a phase IV clinical study of FDA data

Summary:

Hypertonic bladder is reported as a side effect among people who take Donepezil (donepezil hydrochloride), especially for people who are male, 60+ old, also take Myrbetriq, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Hypertonic bladder when taking Donepezil. It is created by eHealthMe based on reports of 24,262 people who have side effects when taking Donepezil from the FDA, and is updated regularly.

What is Donepezil?

Donepezil has active ingredients of donepezil hydrochloride. It is often used in dementia. eHealthMe is studying from 24,564 Donepezil users. Check the latest studies of Donepezil.

What is Hypertonic bladder?

Hypertonic bladder (bladder-storage function that causes a sudden urge to urinate) is found to be associated with 593 drugs and 520 conditions by eHealthMe. Check the latest studies of Hypertonic bladder.

On Jul, 10, 2026

24,262 people reported to have side effects when taking Donepezil.
Among them, 11 people (0.05%) have Hypertonic bladder.

Could Donepezil cause Hypertonic bladder?

Among these 11 people:

What is the gender of people who have Hypertonic bladder when taking Donepezil? *

female: 45.45 %
male: 54.55 %

What is the age of people who have Hypertonic bladder when taking Donepezil? *

What are other drugs people take besides Donepezil? *

What are other side effects people have besides Hypertonic bladder? *

Urinary Incontinence (inability to control the flow of urine and involuntary urination): 7 people, 63.64%
Fall: 7 people, 63.64%
Urinary Tract Infection: 6 people, 54.55%
Nausea And Vomiting: 5 people, 45.45%
Gait Disturbance: 5 people, 45.45%
Balance Disorder: 5 people, 45.45%
Fatigue (feeling of tiredness): 5 people, 45.45%
Weight Decreased: 4 people, 36.36%
Insomnia (sleeplessness): 4 people, 36.36%
Dizziness: 4 people, 36.36%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 45.45%
Pain: 3 people, 27.27%
Hallucinations (sensations that appear real but are created by your mind): 3 people, 27.27%
Delusion (a false belief or opinion): 3 people, 27.27%
Obsessive-Compulsive Disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;): 1 person, 9.09%
Depression: 1 person, 9.09%
Bipolar Disorder (mood disorder): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Donepezil and have Hypertonic bladder?

- Check whether Hypertonic bladder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Donepezil:

Donepezil (24,564 reports)

Browse all side effects of Donepezil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypertonic bladder:

Hypertonic bladder (593 drugs)

Browse all the conditions that are associated with Hypertonic bladder:

Hypertonic bladder (520 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on donepezil hydrochloride (the active ingredients of Donepezil) and Donepezil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.