Donepezil and Hypomagnesaemia - a phase IV clinical study of FDA data

Summary:

Hypomagnesaemia is reported as a side effect among people who take Donepezil (donepezil hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Metformin, and have Indigestion.

The phase IV clinical study analyzes which people have Hypomagnesaemia when taking Donepezil. It is created by eHealthMe based on reports of 24,262 people who have side effects when taking Donepezil from the FDA, and is updated regularly.

What is Donepezil?

Donepezil has active ingredients of donepezil hydrochloride. It is often used in dementia. eHealthMe is studying from 24,564 Donepezil users. Check the latest studies of Donepezil.

What is Hypomagnesaemia?

Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood) is found to be associated with 1,028 drugs and 1,056 conditions by eHealthMe. Check the latest studies of Hypomagnesaemia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

24,262 people reported to have side effects when taking Donepezil.
Among them, 17 people (0.07%) have Hypomagnesaemia.

Among these 17 people:

How long have people been on Donepezil when they have Hypomagnesaemia? *

What is the gender of people who have Hypomagnesaemia when taking Donepezil? *

female: 83.33 %
male: 16.67 %

What is the age of people who have Hypomagnesaemia when taking Donepezil? *

What are other drugs people take besides Donepezil? *

What are other side effects people have besides Hypomagnesaemia? *

Hypocalcaemia (levels of calcium in blood serum are abnormally low): 9 people, 52.94%
Abnormal Behavior: 7 people, 41.18%
Hypokalemia (low potassium): 6 people, 35.29%
Ventricular Tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart): 4 people, 23.53%
Electrocardiogram Qt Prolonged: 4 people, 23.53%
Torsade De Pointes (a abnormal heart rate with abnormal beating pattern): 3 people, 17.65%
Weakness: 2 people, 11.76%
Dehydration (dryness resulting from the removal of water): 2 people, 11.76%
Fainting (loss of consciousness and postural tone): 2 people, 11.76%
Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 2 people, 11.76%

What are the existing conditions these people have? *

Indigestion: 7 people, 41.18%
Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 3 people, 17.65%
Cardiac Failure: 2 people, 11.76%
Urinary Tract Infection: 1 person, 5.88%
Prostate Cancer: 1 person, 5.88%
Oedema Peripheral (superficial swelling): 1 person, 5.88%
High Blood Pressure: 1 person, 5.88%
Depression: 1 person, 5.88%
Constipation: 1 person, 5.88%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Donepezil and have Hypomagnesaemia?

- Check whether Hypomagnesaemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Donepezil:

Donepezil (24,564 reports)

Hypomagnesaemia treatments and more:

Hypomagnesaemia (18,707 reports)

Browse all side effects of Donepezil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypomagnesaemia:

Hypomagnesaemia (1,028 drugs)

Browse all the conditions that are associated with Hypomagnesaemia:

Hypomagnesaemia (1,056 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on donepezil hydrochloride (the active ingredients of Donepezil) and Donepezil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.