Doxycycline hyclate and Fluid retention - a phase IV clinical study of FDA data

Summary:

Fluid retention is reported as a side effect among people who take Doxycycline hyclate (doxycycline hyclate), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Vitamin D3, and have Narcolepsy.

The phase IV clinical study analyzes which people have Fluid retention when taking Doxycycline hyclate. It is created by eHealthMe based on reports of 16,516 people who have side effects when taking Doxycycline hyclate from the FDA, and is updated regularly.

What is Doxycycline hyclate?

Doxycycline hyclate has active ingredients of doxycycline hyclate. It is often used in acne. eHealthMe is studying from 17,884 Doxycycline hyclate users. Check the latest studies of Doxycycline hyclate.

What is Fluid retention?

Fluid retention (an abnormal accumulation of fluid in the blood) is found to be associated with 1,705 drugs and 2,442 conditions by eHealthMe. Check the latest studies of Fluid retention.

On Jul, 04, 2026

16,516 people reported to have side effects when taking Doxycycline hyclate.
Among them, 70 people (0.42%) have Fluid retention.

Could Doxycycline hyclate cause Fluid retention?

Among these 70 people:

How long have people been on Doxycycline hyclate when they have Fluid retention? *

What is the gender of people who have Fluid retention when taking Doxycycline hyclate? *

female: 73.13 %
male: 26.87 %

What is the age of people who have Fluid retention when taking Doxycycline hyclate? *

What are other drugs people take besides Doxycycline hyclate? *

What are other side effects people have besides Fluid retention? *

Dyspnea (difficult or laboured breathing): 26 people, 37.14%
Fatigue (feeling of tiredness): 24 people, 34.29%
Headache (pain in head): 23 people, 32.86%
Diarrhea: 14 people, 20.00%
Peripheral Swelling: 13 people, 18.57%
Chest Pain: 12 people, 17.14%
Memory Loss: 12 people, 17.14%
Nausea And Vomiting: 12 people, 17.14%
Nausea (feeling of having an urge to vomit): 12 people, 17.14%
Cough: 12 people, 17.14%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 14 people, 20.00%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 11 people, 15.71%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 8.57%
Immunodeficiency Common Variable: 5 people, 7.14%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 5.71%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 4 people, 5.71%
Headache (pain in head): 3 people, 4.29%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 4.29%
Drowsiness: 3 people, 4.29%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 2 people, 2.86%

* Approximation only. Some reports may have incomplete information.

Do you take Doxycycline hyclate and have Fluid retention?

- Check whether Fluid retention is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Doxycycline hyclate:

Doxycycline hyclate (17,884 reports)

Fluid retention treatments and more:

Fluid retention (79,660 reports)

Browse all side effects of Doxycycline hyclate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Fluid retention:

Fluid retention (1,705 drugs)

Browse all the conditions that are associated with Fluid retention:

Fluid retention (2,442 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on doxycycline hyclate (the active ingredients of Doxycycline hyclate) and Doxycycline hyclate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.