Doxycycline and Joint crepitation - a phase IV clinical study of FDA data

Summary:

Joint crepitation is reported as a side effect among people who take Doxycycline (doxycycline hyclate), especially for people who are female, 50-59 old, also take Aredia, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Joint crepitation when taking Doxycycline. It is created by eHealthMe based on reports of 57,458 people who have side effects when taking Doxycycline from the FDA, and is updated regularly.

What is Doxycycline?

Doxycycline has active ingredients of doxycycline hyclate. It is often used in acne. eHealthMe is studying from 60,866 Doxycycline users. Check the latest studies of Doxycycline.

What is Joint crepitation?

Joint crepitation is found to be associated with 289 drugs and 739 conditions by eHealthMe. Check the latest studies of Joint crepitation.

On Jul, 11, 2026

57,458 people reported to have side effects when taking Doxycycline.
Among them, 34 people (0.06%) have Joint crepitation.

Could Doxycycline cause Joint crepitation?

Among these 34 people:

What is the gender of people who have Joint crepitation when taking Doxycycline? *

female: 75.76 %
male: 24.24 %

What is the age of people who have Joint crepitation when taking Doxycycline? *

What are other drugs people take besides Doxycycline? *

What are other side effects people have besides Joint crepitation? *

Pain: 28 people, 82.35%
Osteonecrosis Of Jaw (death of bone of jaw): 26 people, 76.47%
Pain In Jaw: 26 people, 76.47%
Scoliosis (a medical condition in which a person's spine is curved from side to side): 26 people, 76.47%
Joint Dislocation (a joint position is changed from normal position): 24 people, 70.59%
Bone Disorder: 24 people, 70.59%
Neuropathy Peripheral (surface nerve damage): 24 people, 70.59%
Osteomyelitis (infection of bone): 24 people, 70.59%
Chronic Renal Failure (kidney failure): 23 people, 67.65%
Pleural Effusion (water on the lungs): 23 people, 67.65%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 21 people, 61.76%
Hypercalcaemia Of Malignancy (elevated calcium (ca+) level in the blood with cancer): 18 people, 52.94%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 13 people, 38.24%
Osteoporosis (bones weak and more likely to break): 6 people, 17.65%
Breast Cancer: 2 people, 5.88%
High Blood Pressure: 2 people, 5.88%
Metastases To Bone (cancer spreads to bone): 2 people, 5.88%
Stress And Anxiety: 2 people, 5.88%
Nasopharyngitis (inflammation of the nasopharynx): 2 people, 5.88%
Muscle Rigidity (muscle stiffness): 1 person, 2.94%

* Approximation only. Some reports may have incomplete information.

Do you take Doxycycline and have Joint crepitation?

- Check whether Joint crepitation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Doxycycline:

Doxycycline (60,866 reports)

Browse all side effects of Doxycycline:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Joint crepitation:

Joint crepitation (289 drugs)

Browse all the conditions that are associated with Joint crepitation:

Joint crepitation (739 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on doxycycline hyclate (the active ingredients of Doxycycline) and Doxycycline (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.