Doxycycline and Left ventricular hypertrophy - a phase IV clinical study of FDA data

Summary:

Left ventricular hypertrophy is reported as a side effect among people who take Doxycycline (doxycycline hyclate), especially for people who are male, 60+ old, also take Zometa, and have Depression.

The phase IV clinical study analyzes which people have Left ventricular hypertrophy when taking Doxycycline. It is created by eHealthMe based on reports of 57,458 people who have side effects when taking Doxycycline from the FDA, and is updated regularly.

What is Doxycycline?

Doxycycline has active ingredients of doxycycline hyclate. It is often used in acne. eHealthMe is studying from 60,868 Doxycycline users. Check the latest studies of Doxycycline.

What is Left ventricular hypertrophy?

Left ventricular hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart) is found to be associated with 896 drugs and 756 conditions by eHealthMe. Check the latest studies of Left ventricular hypertrophy.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

57,458 people reported to have side effects when taking Doxycycline.
Among them, 69 people (0.12%) have Left ventricular hypertrophy.

Could Doxycycline cause Left ventricular hypertrophy?

Among these 69 people:

What is the gender of people who have Left ventricular hypertrophy when taking Doxycycline? *

female: 26.23 %
male: 73.77 %

What is the age of people who have Left ventricular hypertrophy when taking Doxycycline? *

What are other drugs people take besides Doxycycline? *

What are other side effects people have besides Left ventricular hypertrophy? *

High Blood Pressure: 49 people, 71.01%
Stress And Anxiety: 47 people, 68.12%
Cough: 46 people, 66.67%
Nausea (feeling of having an urge to vomit): 44 people, 63.77%
Dyspnea (difficult or laboured breathing): 40 people, 57.97%
Osteonecrosis Of Jaw (death of bone of jaw): 38 people, 55.07%
Mitral Valve Incompetence (inefficient heart valve): 36 people, 52.17%
Musculoskeletal Chest Pain (pain in chest muscle or nerve or bones): 34 people, 49.28%
Pain In Extremity: 34 people, 49.28%
Dizziness: 34 people, 49.28%

What are the existing conditions these people have? *

Depression: 11 people, 15.94%
Sleep Disorder: 9 people, 13.04%
Nausea (feeling of having an urge to vomit): 9 people, 13.04%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 8 people, 11.59%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 8 people, 11.59%
Muscle Spasms (muscle contraction): 8 people, 11.59%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 4.35%
Heart Rate Irregular: 2 people, 2.90%
High Blood Pressure: 2 people, 2.90%
Multiple Myeloma (cancer of the plasma cells): 2 people, 2.90%

* Approximation only. Some reports may have incomplete information.

Do you take Doxycycline and have Left ventricular hypertrophy?

- Check whether Left ventricular hypertrophy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Doxycycline:

Doxycycline (60,868 reports)

Browse all side effects of Doxycycline:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Left ventricular hypertrophy:

Left ventricular hypertrophy (896 drugs)

Browse all the conditions that are associated with Left ventricular hypertrophy:

Left ventricular hypertrophy (756 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on doxycycline hyclate (the active ingredients of Doxycycline) and Doxycycline (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.