Doxycycline and Marrow hyperplasia - a phase IV clinical study of FDA data

Summary:

Marrow hyperplasia is reported as a side effect among people who take Doxycycline (doxycycline hyclate), especially for people who are male, 60+ old, also take Biaxin, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Marrow hyperplasia when taking Doxycycline. It is created by eHealthMe based on reports of 57,458 people who have side effects when taking Doxycycline from the FDA, and is updated regularly.

What is Doxycycline?

Doxycycline has active ingredients of doxycycline hyclate. It is often used in acne. eHealthMe is studying from 60,868 Doxycycline users. Check the latest studies of Doxycycline.

What is Marrow hyperplasia?

Marrow hyperplasia (increased bone marrow) is found to be associated with 278 drugs and 313 conditions by eHealthMe. Check the latest studies of Marrow hyperplasia.

On Aug, 01, 2026

57,458 people reported to have side effects when taking Doxycycline.
Among them, 33 people (0.06%) have Marrow hyperplasia.

Could Doxycycline cause Marrow hyperplasia?

Among these 33 people:

What is the gender of people who have Marrow hyperplasia when taking Doxycycline? *

female: 12.5 %
male: 87.5 %

What is the age of people who have Marrow hyperplasia when taking Doxycycline? *

What are other drugs people take besides Doxycycline? *

What are other side effects people have besides Marrow hyperplasia? *

Headache (pain in head): 28 people, 84.85%
Anaemia (lack of blood): 28 people, 84.85%
Spinal Osteoarthritis (joint cartilage loss in spine): 24 people, 72.73%
Nausea (feeling of having an urge to vomit): 24 people, 72.73%
Pain In Jaw: 24 people, 72.73%
Intervertebral Disc Degeneration (spinal disc degeneration): 24 people, 72.73%
High Blood Cholesterol: 24 people, 72.73%
Sinusitis (inflammation of sinus): 24 people, 72.73%
Stress And Anxiety: 24 people, 72.73%
Renal Cyst (kidney cyst): 21 people, 63.64%

What are the existing conditions these people have? *

Trismus (reduced opening of the jaws): 17 people, 51.52%
Multiple Myeloma (cancer of the plasma cells): 17 people, 51.52%
Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 4 people, 12.12%
Renal Tubular Necrosis (death of kidney tubules): 3 people, 9.09%
Splenomegaly (enlargement of spleen): 2 people, 6.06%
Pulmonary Function Test Decreased: 2 people, 6.06%
High Blood Cholesterol: 2 people, 6.06%
Fever: 2 people, 6.06%
Epstein-Barr Virus Infection: 2 people, 6.06%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 3.03%

* Approximation only. Some reports may have incomplete information.

Do you take Doxycycline and have Marrow hyperplasia?

- Check whether Marrow hyperplasia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Doxycycline:

Doxycycline (60,868 reports)

Browse all side effects of Doxycycline:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Marrow hyperplasia:

Marrow hyperplasia (278 drugs)

Browse all the conditions that are associated with Marrow hyperplasia:

Marrow hyperplasia (313 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on doxycycline hyclate (the active ingredients of Doxycycline) and Doxycycline (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.