Doxycycline and Overlap syndrome - a phase IV clinical study of FDA data

Summary:

Overlap syndrome is reported as a side effect among people who take Doxycycline (doxycycline hyclate), especially for people who are female, 30-39 old, also take Enbrel, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Overlap syndrome when taking Doxycycline. It is created by eHealthMe based on reports of 57,458 people who have side effects when taking Doxycycline from the FDA, and is updated regularly.

What is Doxycycline?

Doxycycline has active ingredients of doxycycline hyclate. It is often used in acne. eHealthMe is studying from 60,868 Doxycycline users. Check the latest studies of Doxycycline.

What is Overlap syndrome?

Overlap syndrome (an autoimmune disease of connective tissue) is found to be associated with 61 drugs and 116 conditions by eHealthMe. Check the latest studies of Overlap syndrome.

On Aug, 13, 2026

57,458 people reported to have side effects when taking Doxycycline.
Among them, 30 people (0.05%) have Overlap syndrome.

Could Doxycycline cause Overlap syndrome?

Among these 30 people:

What is the gender of people who have Overlap syndrome when taking Doxycycline? *

female: 96.15 %
male: 3.85 %

What is the age of people who have Overlap syndrome when taking Doxycycline? *

What are other drugs people take besides Doxycycline? *

What are other side effects people have besides Overlap syndrome? *

Joint Pain: 29 people, 96.67%
Nausea (feeling of having an urge to vomit): 29 people, 96.67%
Vasculitis (inflammation of a blood vessel or blood vessels): 29 people, 96.67%
Jaw Fracture: 29 people, 96.67%
Chest Pain: 29 people, 96.67%
Joint Swelling: 29 people, 96.67%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 29 people, 96.67%
C-Reactive Protein Abnormal: 29 people, 96.67%
Neck Pain: 29 people, 96.67%
Pain In Extremity: 29 people, 96.67%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 29 people, 96.67%

* Approximation only. Some reports may have incomplete information.

Do you take Doxycycline and have Overlap syndrome?

- Check whether Overlap syndrome is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Doxycycline:

Doxycycline (60,868 reports)

Browse all side effects of Doxycycline:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Overlap syndrome:

Overlap syndrome (61 drugs)

Browse all the conditions that are associated with Overlap syndrome:

Overlap syndrome (116 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on doxycycline hyclate (the active ingredients of Doxycycline) and Doxycycline (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.