Duopa and Flat affect - a phase IV clinical study of FDA data

Summary:

Flat affect is reported as a side effect among people who take Duopa (carbidopa; levodopa), especially for people who are male, 60+ old, have been taking the drug for 2 - 5 years also take Sinemet, and have Parkinson's disease.

The phase IV clinical study analyzes which people have Flat affect when taking Duopa. It is created by eHealthMe based on reports of 8,206 people who have side effects when taking Duopa from the FDA, and is updated regularly.

What is Duopa?

Duopa has active ingredients of carbidopa; levodopa. eHealthMe is studying from 8,208 Duopa users. Check the latest studies of Duopa.

What is Flat affect?

Flat affect (absence of emotional response to a situation) is found to be associated with 305 drugs and 454 conditions by eHealthMe. Check the latest studies of Flat affect.

On Dec, 21, 2025

8,206 people reported to have side effects when taking Duopa.
Among them, 10 people (0.12%) have Flat affect.

Among these 10 people:

How long have people been on Duopa when they have Flat affect? *

What is the gender of people who have Flat affect when taking Duopa? *

female: 0.0 %
male: 100 %

What is the age of people who have Flat affect when taking Duopa? *

What are other drugs people take besides Duopa? *

What are other side effects people have besides Flat affect? *

Hallucinations (sensations that appear real but are created by your mind): 10 people, 100.00%
Delirium (wild excitement): 8 people, 80.00%
Confusional State: 6 people, 60.00%
Drowsiness: 6 people, 60.00%
Weight Decreased: 5 people, 50.00%
Vitamin D Decreased: 5 people, 50.00%
Glaucoma (increased fluid pressure in the eye with vision loss): 5 people, 50.00%
Personality Change: 5 people, 50.00%
Fall: 5 people, 50.00%
Dyskinesia (abnormality or impairment of voluntary movement): 5 people, 50.00%

What are the existing conditions these people have? *

Parkinson's Disease: 9 people, 90.00%
Hallucinations (sensations that appear real but are created by your mind): 7 people, 70.00%
Stress And Anxiety: 7 people, 70.00%
Ulcer Haemorrhage (bleeding ulcer): 5 people, 50.00%
Constipation: 5 people, 50.00%
Glaucoma (increased fluid pressure in the eye with vision loss): 5 people, 50.00%
Dyskinesia (abnormality or impairment of voluntary movement): 5 people, 50.00%
Psychotic Disorder: 3 people, 30.00%
Delusion (a false belief or opinion): 3 people, 30.00%
Insomnia (sleeplessness): 3 people, 30.00%

* Approximation only. Some reports may have incomplete information.

Do you take Duopa and have Flat affect?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Duopa:

Duopa (8,208 reports)

Flat affect treatments and more:

Flat affect (2,784 reports)

Browse all side effects of Duopa:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Flat affect:

Flat affect (305 drugs)

Browse all the conditions that are associated with Flat affect:

Flat affect (454 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on carbidopa; levodopa (the active ingredients of Duopa) and Duopa (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.