Duphalac and Coma - a phase IV clinical study of FDA data

Summary:

Coma is reported as a side effect among people who take Duphalac (lactulose), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Lyrica, and have Pain.

The phase IV clinical study analyzes which people have Coma when taking Duphalac. It is created by eHealthMe based on reports of 5,136 people who have side effects when taking Duphalac from the FDA, and is updated regularly.

What is Duphalac?

Duphalac has active ingredients of lactulose. It is often used in constipation. eHealthMe is studying from 5,152 Duphalac users. Check the latest studies of Duphalac.

What is Coma?

Coma (state of unconsciousness lasting more than six hours) is found to be associated with 2,785 drugs and 3,207 conditions by eHealthMe. Check the latest studies of Coma.

On Apr, 19, 2026

5,136 people reported to have side effects when taking Duphalac.
Among them, 88 people (1.71%) have Coma.

Among these 88 people:

How long have people been on Duphalac when they have Coma? *

What is the gender of people who have Coma when taking Duphalac? *

female: 61.18 %
male: 38.82 %

What is the age of people who have Coma when taking Duphalac? *

What are other drugs people take besides Duphalac? *

What are other side effects people have besides Coma? *

Hypotension (abnormally low blood pressure): 19 people, 21.59%
Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 16 people, 18.18%
Bradycardia (abnormally slow heart action): 12 people, 13.64%
Miosis (constriction of the pupil of the eye, resulting from a normal response to an increase in light): 9 people, 10.23%
Hepatic Encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure): 7 people, 7.95%
Confusional State: 7 people, 7.95%
Acute Kidney Failure: 6 people, 6.82%
Disseminated Intravascular Coagulation (systemic activation of blood coagulation): 6 people, 6.82%
Fever: 6 people, 6.82%
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 5 people, 5.68%

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 5 people, 5.68%
Pain: 5 people, 5.68%
Hepatic Encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure): 4 people, 4.55%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 3 people, 3.41%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 3.41%
Type 2 Diabetes: 2 people, 2.27%
Pneumonia Aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree): 2 people, 2.27%
Agitation (state of anxiety or nervous excitement): 2 people, 2.27%
Drug Dependence: 2 people, 2.27%
Herpes Zoster: 2 people, 2.27%

* Approximation only. Some reports may have incomplete information.

Do you take Duphalac and have Coma?

- Check whether Coma is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Duphalac:

Duphalac (5,152 reports)

Coma treatments and more:

Coma (57,420 reports)

Browse all side effects of Duphalac:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Coma:

Coma (2,785 drugs)

Browse all the conditions that are associated with Coma:

Coma (3,207 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on lactulose (the active ingredients of Duphalac) and Duphalac (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.