Effexor xr and Appendicitis perforated - a phase IV clinical study of FDA data

Summary:

Appendicitis perforated is reported as a side effect among people who take Effexor xr (venlafaxine hydrochloride), especially for people who are female, 50-59 old, also take Seroquel, and have Hypothyroidism.

The phase IV clinical study analyzes which people have Appendicitis perforated when taking Effexor xr. It is created by eHealthMe based on reports of 31,325 people who have side effects when taking Effexor xr from the FDA, and is updated regularly.

What is Effexor xr?

Effexor xr has active ingredients of venlafaxine hydrochloride. It is often used in depression. eHealthMe is studying from 35,233 Effexor xr users. Check the latest studies of Effexor xr.

What is Appendicitis perforated?

Appendicitis perforated (perforated appendicitis is a condition in which an inflamed appendix bursts) is found to be associated with 365 drugs and 558 conditions by eHealthMe. Check the latest studies of Appendicitis perforated.

On Aug, 12, 2026

31,325 people reported to have side effects when taking Effexor xr.
Among them, 16 people (0.05%) have Appendicitis perforated.

Could Effexor xr cause Appendicitis perforated?

Among these 16 people:

What is the gender of people who have Appendicitis perforated when taking Effexor xr? *

female: 73.33 %
male: 26.67 %

What is the age of people who have Appendicitis perforated when taking Effexor xr? *

What are other drugs people take besides Effexor xr? *

What are other side effects people have besides Appendicitis perforated? *

Malaise (a feeling of general discomfort or uneasiness): 6 people, 37.50%
Sepsis (a severe blood infection that can lead to organ failure and death): 6 people, 37.50%
Pleurisy (inflammation of the pleurae, which causes pain when breathing): 5 people, 31.25%
Pneumonia: 5 people, 31.25%
Drug Ineffective: 5 people, 31.25%
Psychotic Disorder: 4 people, 25.00%
Hallucinations, Mixed (sensations that appear real but are created by your mind -mixed): 4 people, 25.00%
Aggression: 4 people, 25.00%
Red Blood Cell Count Decreased: 3 people, 18.75%
Blood Creatine Phosphokinase Increased: 3 people, 18.75%

What are the existing conditions these people have? *

Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 25.00%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 3 people, 18.75%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 18.75%
Post-Traumatic Stress Disorder: 2 people, 12.50%
Nightmares (unpleasant dreams): 2 people, 12.50%
Affective Disorder (mental disorder): 2 people, 12.50%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 6.25%
Mood Swings (an extreme or rapid change in mood): 1 person, 6.25%
Essential Tremor: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Effexor xr and have Appendicitis perforated?

- Check whether Appendicitis perforated is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Effexor xr:

Effexor xr (35,233 reports)

Browse all side effects of Effexor xr:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Appendicitis perforated:

Appendicitis perforated (365 drugs)

Browse all the conditions that are associated with Appendicitis perforated:

Appendicitis perforated (558 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on venlafaxine hydrochloride (the active ingredients of Effexor xr) and Effexor xr (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.