Effexor xr and Tendon rupture - a phase IV clinical study of FDA data

Summary:

Tendon rupture is reported as a side effect among people who take Effexor xr (venlafaxine hydrochloride), especially for people who are female, 40-49 old, have been taking the drug for 2 - 5 years also take Neurontin, and have Hepatitis c.

The phase IV clinical study analyzes which people have Tendon rupture when taking Effexor xr. It is created by eHealthMe based on reports of 31,325 people who have side effects when taking Effexor xr from the FDA, and is updated regularly.

What is Effexor xr?

Effexor xr has active ingredients of venlafaxine hydrochloride. It is often used in depression. eHealthMe is studying from 35,233 Effexor xr users. Check the latest studies of Effexor xr.

What is Tendon rupture?

Tendon rupture (tear of tendon) is found to be associated with 803 drugs and 1,060 conditions by eHealthMe. Check the latest studies of Tendon rupture.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 15, 2026

31,325 people reported to have side effects when taking Effexor xr.
Among them, 24 people (0.08%) have Tendon rupture.

Among these 24 people:

How long have people been on Effexor xr when they have Tendon rupture? *

What is the gender of people who have Tendon rupture when taking Effexor xr? *

female: 78.26 %
male: 21.74 %

What is the age of people who have Tendon rupture when taking Effexor xr? *

What are other drugs people take besides Effexor xr? *

What are other side effects people have besides Tendon rupture? *

Pain: 13 people, 54.17%
Joint Pain: 11 people, 45.83%
Memory Loss: 11 people, 45.83%
Muscle Aches (muscle pain): 10 people, 41.67%
Tendonitis (a condition that causes pain and swelling of tendons): 10 people, 41.67%
Drug Ineffective: 8 people, 33.33%
Night Sweats (sweating in night): 8 people, 33.33%
Coughing Up Blood: 8 people, 33.33%
Dehydration (dryness resulting from the removal of water): 8 people, 33.33%
Diplopia (double vision): 8 people, 33.33%

What are the existing conditions these people have? *

Hepatitis C: 8 people, 33.33%
Psoriasis (immune-mediated disease that affects the skin): 3 people, 12.50%
Urinary Tract Infection: 2 people, 8.33%
Pain: 2 people, 8.33%
High Blood Cholesterol: 2 people, 8.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 8.33%
Sinusitis (inflammation of sinus): 1 person, 4.17%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 4.17%
Osteopenia (a condition where bone mineral density is lower than normal): 1 person, 4.17%
Neuralgia (pain in one or more nerves): 1 person, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take Effexor xr and have Tendon rupture?

- Check whether Tendon rupture is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Effexor xr:

Effexor xr (35,233 reports)

Tendon rupture treatments and more:

Tendon rupture (15,907 reports)

Browse all side effects of Effexor xr:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Tendon rupture:

Tendon rupture (803 drugs)

Browse all the conditions that are associated with Tendon rupture:

Tendon rupture (1,060 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on venlafaxine hydrochloride (the active ingredients of Effexor xr) and Effexor xr (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.