Effexor and Large intestine perforation - a phase IV clinical study of FDA data

Summary:

Large intestine perforation is reported as a side effect among people who take Effexor (venlafaxine hydrochloride), especially for people who are female, 60+ old, also take Lipitor, and have Pain.

The phase IV clinical study analyzes which people have Large intestine perforation when taking Effexor. It is created by eHealthMe based on reports of 92,291 people who have side effects when taking Effexor from the FDA, and is updated regularly.

What is Effexor?

Effexor has active ingredients of venlafaxine hydrochloride. It is often used in depression. eHealthMe is studying from 99,496 Effexor users. Check the latest studies of Effexor.

What is Large intestine perforation?

Large intestine perforation (hole in large intestine) is found to be associated with 632 drugs and 794 conditions by eHealthMe. Check the latest studies of Large intestine perforation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

92,291 people reported to have side effects when taking Effexor.
Among them, 19 people (0.02%) have Large intestine perforation.

Could Effexor cause Large intestine perforation?

Among these 19 people:

What is the gender of people who have Large intestine perforation when taking Effexor? *

female: 78.95 %
male: 21.05 %

What is the age of people who have Large intestine perforation when taking Effexor? *

What are other drugs people take besides Effexor? *

What are other side effects people have besides Large intestine perforation? *

Abdominal Pain: 5 people, 26.32%
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs): 4 people, 21.05%
Malaise (a feeling of general discomfort or uneasiness): 3 people, 15.79%
Hypotension (abnormally low blood pressure): 3 people, 15.79%
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle): 2 people, 10.53%
Intestinal Obstruction: 2 people, 10.53%
Intestinal Ischaemia (decreased supply of oxygenated blood to the intestines): 2 people, 10.53%
Constipation: 2 people, 10.53%
Infection: 2 people, 10.53%
Pneumonia: 2 people, 10.53%

What are the existing conditions these people have? *

High Blood Cholesterol: 6 people, 31.58%
Pain: 6 people, 31.58%
Back Pain: 3 people, 15.79%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 15.79%
Colon Cancer Metastatic (cancer of colon spreads to other part of body): 3 people, 15.79%
Multiple Myeloma (cancer of the plasma cells): 3 people, 15.79%
Sleep Disorder: 3 people, 15.79%
Chest Pain: 2 people, 10.53%
Insomnia (sleeplessness): 2 people, 10.53%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 2 people, 10.53%

* Approximation only. Some reports may have incomplete information.

Do you take Effexor and have Large intestine perforation?

- Check whether Large intestine perforation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Effexor:

Effexor (99,496 reports)

Browse all side effects of Effexor:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Large intestine perforation:

Large intestine perforation (632 drugs)

Browse all the conditions that are associated with Large intestine perforation:

Large intestine perforation (794 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on venlafaxine hydrochloride (the active ingredients of Effexor) and Effexor (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.