1. Home
  2. Analysis
  3. Effexor
  4. Local-reaction

Effexor and Local reaction - a phase IV clinical study of FDA data

Summary:

Local reaction is reported as a side effect among people who take Effexor (venlafaxine hydrochloride), especially for people who are female, 60+ old, also take Epinephrine, and have Immunodeficiency common variable.

The phase IV clinical study analyzes which people have Local reaction when taking Effexor. It is created by eHealthMe based on reports of 92,291 people who have side effects when taking Effexor from the FDA, and is updated regularly.

What is Effexor?

Effexor has active ingredients of venlafaxine hydrochloride. It is often used in depression. eHealthMe is studying from 99,493 Effexor users. Check the latest studies of Effexor.

What is Local reaction?

Local reaction (reaction of any substance at the site of use) is found to be associated with 88 drugs and 115 conditions by eHealthMe. Check the latest studies of Local reaction.

On Feb, 10, 2026

92,291 people reported to have side effects when taking Effexor.
Among them, 13 people (0.01%) have Local reaction.

Could Effexor cause Local reaction?

Among these 13 people:

What is the gender of people who have Local reaction when taking Effexor? *

  • female: 92.31 %
  • male: 7.69 %

What is the age of people who have Local reaction when taking Effexor? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 14.29 %
  • 40-49: 42.86 %
  • 50-59: 0.0 %
  • 60+: 42.86 %

What are other drugs people take besides Effexor? *

  1. Acetaminophen: 7 people, 53.85%
  2. Gabapentin: 7 people, 53.85%
  3. Lidocaine: 7 people, 53.85%
  4. Epinephrine: 7 people, 53.85%
  5. Botox: 5 people, 38.46%
  6. Estradiol: 5 people, 38.46%
  7. Doxycycline Hyclate: 5 people, 38.46%
  8. Doxycycline: 5 people, 38.46%
  9. Dexilant: 5 people, 38.46%
  10. Cymbalta: 5 people, 38.46%

What are other side effects people have besides Local reaction? *

  1. Urinary Tract Infection: 8 people, 61.54%
  2. Infection: 8 people, 61.54%
  3. Sinusitis (inflammation of sinus): 7 people, 53.85%
  4. Otitis (ear infection): 5 people, 38.46%
  5. Blood Iron Decreased: 5 people, 38.46%
  6. Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall): 5 people, 38.46%
  7. Heart Attack: 5 people, 38.46%
  8. Infusion Site Erythema (reddening of the skin at infusion site): 5 people, 38.46%
  9. Infusion Site Swelling: 5 people, 38.46%
  10. Infusion Site Pain: 5 people, 38.46%

What are the existing conditions these people have? *

  1. Immunodeficiency Common Variable: 12 people, 92.31%
  2. Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 7.69%
  3. Primary Immunodeficiency Syndrome: 1 person, 7.69%
  4. Pneumonia: 1 person, 7.69%
  5. Indigestion: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Effexor and have Local reaction?

- Check whether Local reaction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Effexor:

Local reaction treatments and more:

How severe was Local reaction and when was it recovered:

Expand to all the drugs that have ingredients of venlafaxine hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Effexor:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Local reaction:

Browse all the conditions that are associated with Local reaction:

How the study uses the data?

The study uses data from the FDA. It is based on venlafaxine hydrochloride (the active ingredients of Effexor) and Effexor (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe:

© 2026 eHealthMe.com. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy.