Efudex and Skin irritation - a phase IV clinical study of FDA data

Summary:

Skin irritation is reported as a side effect among people who take Efudex (fluorouracil), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Humira, and have Precancerous skin lesion.

The phase IV clinical study analyzes which people have Skin irritation when taking Efudex. It is created by eHealthMe based on reports of 1,332 people who have side effects when taking Efudex from the FDA, and is updated regularly.

What is Efudex?

Efudex has active ingredients of fluorouracil. It is often used in actinic keratosis. eHealthMe is studying from 1,391 Efudex users. Check the latest studies of Efudex.

What is Skin irritation?

Skin irritation is found to be associated with 967 drugs and 931 conditions by eHealthMe. Check the latest studies of Skin irritation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

1,332 people reported to have side effects when taking Efudex.
Among them, 15 people (1.13%) have Skin irritation.

Among these 15 people:

How long have people been on Efudex when they have Skin irritation? *

What is the gender of people who have Skin irritation when taking Efudex? *

female: 60 %
male: 40 %

What is the age of people who have Skin irritation when taking Efudex? *

What are other drugs people take besides Efudex? *

What are other side effects people have besides Skin irritation? *

Rashes (redness): 6 people, 40.00%
Dizziness: 3 people, 20.00%
Muscle Aches (muscle pain): 2 people, 13.33%
Drug Ineffective: 2 people, 13.33%
Skin Exfoliation (removal of the oldest dead skin cells): 2 people, 13.33%
Headache (pain in head): 2 people, 13.33%
Weakness: 2 people, 13.33%
High Blood Pressure: 2 people, 13.33%
Visual Impairment: 2 people, 13.33%
Malaise (a feeling of general discomfort or uneasiness): 2 people, 13.33%

What are the existing conditions these people have? *

Skin Disorder (skin disease): 2 people, 13.33%
Rashes (redness): 2 people, 13.33%
Precancerous Skin Lesion: 2 people, 13.33%
Staphylococcal Skin Infection (skin infection by an infection with staphylococcus bacteria): 1 person, 6.67%
Hyperkeratosis (thickening of the outer layer of the skin): 1 person, 6.67%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 6.67%
B-Cell Small Lymphocytic Lymphoma (blood cancer affecting b cells): 1 person, 6.67%
Cardiac Failure Congestive: 1 person, 6.67%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 1 person, 6.67%
High Blood Cholesterol: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Efudex and have Skin irritation?

- Check whether Skin irritation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Efudex:

Efudex (1,391 reports)

Skin irritation treatments and more:

Skin irritation (45,467 reports)

Browse all side effects of Efudex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Skin irritation:

Skin irritation (967 drugs)

Browse all the conditions that are associated with Skin irritation:

Skin irritation (931 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on fluorouracil (the active ingredients of Efudex) and Efudex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.