Elavil and Cystitis interstitial - a phase IV clinical study of FDA data

Summary:

Cystitis interstitial is reported as a side effect among people who take Elavil (amitriptyline hydrochloride), especially for people who are female, 60+ old, also take Vagifem, and have Osteoporosis.

The phase IV clinical study analyzes which people have Cystitis interstitial when taking Elavil. It is created by eHealthMe based on reports of 19,133 people who have side effects when taking Elavil from the FDA, and is updated regularly.

What is Elavil?

Elavil has active ingredients of amitriptyline hydrochloride. It is often used in depression. eHealthMe is studying from 20,724 Elavil users. Check the latest studies of Elavil.

What is Cystitis interstitial?

Cystitis interstitial (unknown cause characterized by bladder pain) is found to be associated with 332 drugs and 439 conditions by eHealthMe. Check the latest studies of Cystitis interstitial.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

19,133 people reported to have side effects when taking Elavil.
Among them, 34 people (0.18%) have Cystitis interstitial.

Could Elavil cause Cystitis interstitial?

Among these 34 people:

What is the gender of people who have Cystitis interstitial when taking Elavil? *

female: 96.77 %
male: 3.23 %

What is the age of people who have Cystitis interstitial when taking Elavil? *

What are other drugs people take besides Elavil? *

What are other side effects people have besides Cystitis interstitial? *

Fall: 23 people, 67.65%
Nausea (feeling of having an urge to vomit): 21 people, 61.76%
Joint Pain: 21 people, 61.76%
Stress And Anxiety: 21 people, 61.76%
Intervertebral Disc Protrusion (spinal disc protrusion): 20 people, 58.82%
Joint Effusion (presence of extra fluid in joint covering): 20 people, 58.82%
Foot Deformity (functional disability of foot): 20 people, 58.82%
Pain In Extremity: 20 people, 58.82%
Diarrhea: 20 people, 58.82%
Femur Fracture: 20 people, 58.82%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 15 people, 44.12%
Sleep Disorder: 11 people, 32.35%
Osteopenia (a condition where bone mineral density is lower than normal): 10 people, 29.41%
Breast Cancer: 8 people, 23.53%
Metastases To Bone (cancer spreads to bone): 4 people, 11.76%
Multiple Myeloma (cancer of the plasma cells): 4 people, 11.76%
High Blood Pressure: 3 people, 8.82%
High Blood Cholesterol: 2 people, 5.88%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 2 people, 5.88%
Indigestion: 1 person, 2.94%

* Approximation only. Some reports may have incomplete information.

Do you take Elavil and have Cystitis interstitial?

- Check whether Cystitis interstitial is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Elavil:

Elavil (20,724 reports)

Browse all side effects of Elavil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cystitis interstitial:

Cystitis interstitial (332 drugs)

Browse all the conditions that are associated with Cystitis interstitial:

Cystitis interstitial (439 conditions)

Related publications that referenced our studies

Li W, Lamichhane J, "From Heartbreak to Left Bundle Branch Block: A Case of Amitriptyline Overdose", American Journal of Therapeutics, 2017 Sep .
Li W, Lamichhane J, "From Heartbreak to Left Bundle Branch Block: A Case of Amitriptyline Overdose", American Journal of Therapeutics, 2017 Sep .

How the study uses the data?

The study uses data from the FDA. It is based on amitriptyline hydrochloride (the active ingredients of Elavil) and Elavil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.