Elavil and Synovitis - a phase IV clinical study of FDA data

Summary:

Synovitis is reported as a side effect among people who take Elavil (amitriptyline hydrochloride), especially for people who are female, 60+ old, also take Humira, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Synovitis when taking Elavil. It is created by eHealthMe based on reports of 19,133 people who have side effects when taking Elavil from the FDA, and is updated regularly.

What is Elavil?

Elavil has active ingredients of amitriptyline hydrochloride. It is often used in depression. eHealthMe is studying from 20,723 Elavil users. Check the latest studies of Elavil.

What is Synovitis?

Synovitis (inflammation of the synovial membrane) is found to be associated with 698 drugs and 508 conditions by eHealthMe. Check the latest studies of Synovitis.

On Apr, 11, 2026

19,133 people reported to have side effects when taking Elavil.
Among them, 211 people (1.1%) have Synovitis.

Among these 211 people:

* Approximation only. Some reports may have incomplete information.

Do you take Elavil and have Synovitis?

- Check whether Synovitis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Elavil:

Elavil (20,723 reports)

Synovitis treatments and more:

Synovitis (24,130 reports)

How severe was Synovitis and when was it recovered:

Synovitis in Elavil

Expand to all the drugs that have ingredients of amitriptyline hydrochloride:

Synovitis and drugs with ingredients of amitriptyline hydrochloride (400 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Elavil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Synovitis:

Synovitis (698 drugs)

Browse all the conditions that are associated with Synovitis:

Synovitis (508 conditions)

Related publications that referenced our studies

Li W, Lamichhane J, "From Heartbreak to Left Bundle Branch Block: A Case of Amitriptyline Overdose", American Journal of Therapeutics, 2017 Sep .
Li W, Lamichhane J, "From Heartbreak to Left Bundle Branch Block: A Case of Amitriptyline Overdose", American Journal of Therapeutics, 2017 Sep .

How the study uses the data?

The study uses data from the FDA. It is based on amitriptyline hydrochloride (the active ingredients of Elavil) and Elavil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.