Eliquis and Cell death - a phase IV clinical study of FDA data

Summary:

Cell death is reported as a side effect among people who take Eliquis (apixaban), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Amlodipine, and have Hypothyroidism.

The study is created by eHealthMe based on reports of 189,425 people who have side effects when taking Eliquis from the FDA, and is updated regularly.

What is Eliquis?

Eliquis has active ingredients of apixaban. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 191,861 Eliquis users. Check the latest studies of Eliquis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

189,425 people reported to have side effects when taking Eliquis.
Among them, 32 people (0.02%) died.

Among these 32 people:

How long have people been on Eliquis when they died? *

What is the gender of people who died when taking Eliquis? *

female: 20.69 %
male: 79.31 %

What is the age of people who died when taking Eliquis? *

What are other drugs people take besides Eliquis? *

Amlodipine: 12 people, 37.50%
Furosemide: 4 people, 12.50%
Cordarone: 3 people, 9.38%
Bactrim: 3 people, 9.38%
Allopurinol: 2 people, 6.25%
Valacyclovir Hydrochloride: 2 people, 6.25%
Trulicity: 2 people, 6.25%
Tresiba: 2 people, 6.25%
Silodosin: 2 people, 6.25%
Paracetamol: 2 people, 6.25%

What are other side effects people have before they died? *

Cholestasis (a condition where bile cannot flow from the liver to the duodenum): 23 people, 71.88%
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 4 people, 12.50%
Fever: 3 people, 9.38%
Weakness: 2 people, 6.25%
Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood): 2 people, 6.25%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 2 people, 6.25%
Back Pain: 2 people, 6.25%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 2 people, 6.25%
Dehydration (dryness resulting from the removal of water): 2 people, 6.25%
Diarrhea: 2 people, 6.25%

What are the existing conditions these people have? *

Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 18 people, 56.25%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 17 people, 53.12%
Iron Deficiency Anaemia: 16 people, 50.00%
Constipation: 16 people, 50.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 16 people, 50.00%
High Blood Pressure: 16 people, 50.00%
Pain: 16 people, 50.00%
Urinary Retention (the inability to completely or partially empty the bladder): 15 people, 46.88%
Anaemia (lack of blood): 15 people, 46.88%
Oedema Peripheral (superficial swelling): 4 people, 12.50%

* Approximation only. Some reports may have incomplete information.

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Eliquis:

Eliquis (191,861 reports)

Expand to all the drugs that have ingredients of apixaban:

Cell death and drugs with ingredients of apixaban

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Eliquis:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cell death:

Cell death (210 drugs)

Browse all the conditions that are associated with Cell death:

Cell death (331 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on apixaban (the active ingredients of Eliquis) and Eliquis (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.