Enablex and Metabolic acidosis - a phase IV clinical study of FDA data

Summary:

Metabolic acidosis is reported as a side effect among people who take Enablex (darifenacin hydrobromide), especially for people who are female, 60+ old, also take Protonix, and have High blood pressure.

The phase IV clinical study analyzes which people have Metabolic acidosis when taking Enablex. It is created by eHealthMe based on reports of 4,746 people who have side effects when taking Enablex from the FDA, and is updated regularly.

What is Enablex?

Enablex has active ingredients of darifenacin hydrobromide. It is often used in urge incontinence. eHealthMe is studying from 4,934 Enablex users. Check the latest studies of Enablex.

What is Metabolic acidosis?

Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body) is found to be associated with 1,416 drugs and 1,660 conditions by eHealthMe. Check the latest studies of Metabolic acidosis.

On Aug, 03, 2026

4,746 people reported to have side effects when taking Enablex.
Among them, 13 people (0.27%) have Metabolic acidosis.

Among these 13 people:

What is the gender of people who have Metabolic acidosis when taking Enablex? *

female: 69.23 %
male: 30.77 %

What is the age of people who have Metabolic acidosis when taking Enablex? *

What are other drugs people take besides Enablex? *

What are other side effects people have besides Metabolic acidosis? *

Pain: 8 people, 61.54%
High Blood Pressure: 7 people, 53.85%
Pneumonia: 7 people, 53.85%
Nausea (feeling of having an urge to vomit): 7 people, 53.85%
Weakness: 7 people, 53.85%
Stress And Anxiety: 6 people, 46.15%
Chronic Renal Failure (kidney failure): 6 people, 46.15%
Weight Decreased: 6 people, 46.15%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 46.15%
Acute Kidney Failure: 6 people, 46.15%

What are the existing conditions these people have? *

High Blood Pressure: 4 people, 30.77%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 15.38%
Bladder Disorder: 2 people, 15.38%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 15.38%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 15.38%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 15.38%
Temporomandibular Joint Syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress): 1 person, 7.69%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 7.69%
Blood Pressure Abnormal: 1 person, 7.69%
Constipation: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Enablex and have Metabolic acidosis?

- Check whether Metabolic acidosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Enablex:

Enablex (4,934 reports)

Browse all side effects of Enablex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Metabolic acidosis:

Metabolic acidosis (1,416 drugs)

Browse all the conditions that are associated with Metabolic acidosis:

Metabolic acidosis (1,660 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on darifenacin hydrobromide (the active ingredients of Enablex) and Enablex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.