Enbrel and Tension headache - a phase IV clinical study of FDA data

Summary:

Tension headache is reported as a side effect among people who take Enbrel (etanercept), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Tenormin, and have Psoriasis.

The phase IV clinical study analyzes which people have Tension headache when taking Enbrel. It is created by eHealthMe based on reports of 662,905 people who have side effects when taking Enbrel from the FDA, and is updated regularly.

What is Enbrel?

Enbrel has active ingredients of etanercept. It is often used in rheumatoid arthritis. eHealthMe is studying from 664,678 Enbrel users. Check the latest studies of Enbrel.

What is Tension headache?

Tension headache is found to be associated with 542 drugs and 964 conditions by eHealthMe. Check the latest studies of Tension headache.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

662,905 people reported to have side effects when taking Enbrel.
Among them, 77 people (0.01%) have Tension headache.

Among these 77 people:

How long have people been on Enbrel when they have Tension headache? *

What is the gender of people who have Tension headache when taking Enbrel? *

female: 77.63 %
male: 22.37 %

What is the age of people who have Tension headache when taking Enbrel? *

What are other drugs people take besides Enbrel? *

Arthrotec: 7 people, 9.09%
Nasonex: 7 people, 9.09%
Diclofenac Sodium And Misoprostol: 7 people, 9.09%
Pantoprazole: 7 people, 9.09%
Diovan: 7 people, 9.09%
Bricanyl: 7 people, 9.09%
Synthroid: 7 people, 9.09%
Fiorinal: 7 people, 9.09%
Codeine: 7 people, 9.09%
Tenormin: 7 people, 9.09%

What are other side effects people have besides Tension headache? *

Headache (pain in head): 22 people, 28.57%
Fatigue (feeling of tiredness): 13 people, 16.88%
Migraine (headache): 12 people, 15.58%
High Blood Pressure: 12 people, 15.58%
Sinus Headache (headache caused by sinus infections): 11 people, 14.29%
Pain: 10 people, 12.99%
Nausea (feeling of having an urge to vomit): 9 people, 11.69%
Drowsiness: 9 people, 11.69%
Joint Pain: 9 people, 11.69%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 11.69%

What are the existing conditions these people have? *

Psoriasis (immune-mediated disease that affects the skin): 12 people, 15.58%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 7 people, 9.09%
Pain: 7 people, 9.09%
Gastrointestinal Pain: 7 people, 9.09%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 1 person, 1.30%
Stress And Anxiety: 1 person, 1.30%
Muscle Spasms (muscle contraction): 1 person, 1.30%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 1.30%
Mouth Ulcers: 1 person, 1.30%
Hypersensitivity: 1 person, 1.30%

* Approximation only. Some reports may have incomplete information.

Do you take Enbrel and have Tension headache?

- Check whether Tension headache is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Enbrel:

Enbrel (664,678 reports)

Browse all side effects of Enbrel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Tension headache:

Tension headache (542 drugs)

Browse all the conditions that are associated with Tension headache:

Tension headache (964 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on etanercept (the active ingredients of Enbrel) and Enbrel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.