Endari and Adverse event - a phase IV clinical study of FDA data

Summary:

Adverse event is reported as a side effect among people who take Endari (l-glutamine), especially for people who are female, 20-29 old, have been taking the drug for 6 - 12 months also take Hydroxyurea, and have Pain.

The phase IV clinical study analyzes which people have Adverse event when taking Endari. It is created by eHealthMe based on reports of 2,785 people who have side effects when taking Endari from the FDA, and is updated regularly.

What is Endari?

Endari has active ingredients of l-glutamine. eHealthMe is studying from 2,785 Endari users. Check the latest studies of Endari.

What is Adverse event?

Adverse event is found to be associated with 1,681 drugs and 1,672 conditions by eHealthMe. Check the latest studies of Adverse event.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

2,785 people reported to have side effects when taking Endari.
Among them, 87 people (3.12%) have Adverse event.

Among these 87 people:

How long have people been on Endari when they have Adverse event? *

What is the gender of people who have Adverse event when taking Endari? *

female: 59.77 %
male: 40.23 %

What is the age of people who have Adverse event when taking Endari? *

What are other drugs people take besides Endari? *

What are other side effects people have besides Adverse event? *

Hospitalisation: 5 people, 5.75%
Pain In Extremity: 4 people, 4.60%
Malaise (a feeling of general discomfort or uneasiness): 4 people, 4.60%
Headache (pain in head): 2 people, 2.30%
Acute Chest Syndrome (acute chest pain, fever and difficulty breathing): 2 people, 2.30%
Aseptic Necrosis (the death of bone tissue due to a lack of blood supply): 2 people, 2.30%
Back Pain: 2 people, 2.30%
Constipation: 2 people, 2.30%
Diarrhea: 2 people, 2.30%
Drug Ineffective: 2 people, 2.30%

What are the existing conditions these people have? *

Pain: 3 people, 3.45%
Migraine (headache): 1 person, 1.15%
Jugular Vein Thrombosis (clot in jugular vein): 1 person, 1.15%
High Blood Pressure: 1 person, 1.15%
Haemochromatosis (body to absorb more iron than usual from food): 1 person, 1.15%
Diabetes: 1 person, 1.15%

* Approximation only. Some reports may have incomplete information.

Do you take Endari and have Adverse event?

- Check whether Adverse event is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Endari:

Endari (2,785 reports)

Adverse event treatments and more:

Adverse event (100,133 reports)

Browse all side effects of Endari:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Adverse event:

Adverse event (1,681 drugs)

Browse all the conditions that are associated with Adverse event:

Adverse event (1,672 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on l-glutamine (the active ingredients of Endari) and Endari (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.