Endep and Constipation - a phase IV clinical study of FDA data

Summary:

Constipation is reported as a side effect among people who take Endep (amitriptyline hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years also take Panadol, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Constipation when taking Endep. It is created by eHealthMe based on reports of 864 people who have side effects when taking Endep from the FDA, and is updated regularly.

What is Endep?

Endep has active ingredients of amitriptyline hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 1,301 Endep users. Check the latest studies of Endep.

What is Constipation?

Constipation is found to be associated with 3,001 drugs and 4,563 conditions by eHealthMe. Check the latest studies of Constipation.

On Nov, 07, 2025

864 people reported to have side effects when taking Endep.
Among them, 38 people (4.4%) have Constipation.

Among these 38 people:

How long have people been on Endep when they have Constipation? *

What is the gender of people who have Constipation when taking Endep? *

female: 94.59 %
male: 5.41 %

What is the age of people who have Constipation when taking Endep? *

What are other drugs people take besides Endep? *

Panadol: 19 people, 50.00%
Lyrica: 17 people, 44.74%
Movicol: 9 people, 23.68%
Valium: 9 people, 23.68%
Valacyclovir Hydrochloride: 8 people, 21.05%
Clexane: 8 people, 21.05%
Enoxaparin Sodium: 5 people, 13.16%
Ranitidine: 5 people, 13.16%
Nystatin: 5 people, 13.16%
Ibuprofen: 5 people, 13.16%

What are other side effects people have besides Constipation? *

Fatigue (feeling of tiredness): 21 people, 55.26%
Weakness: 20 people, 52.63%
Pain: 19 people, 50.00%
Muscle Spasms (muscle contraction): 19 people, 50.00%
Urinary Tract Infection: 17 people, 44.74%
Urinary Retention (the inability to completely or partially empty the bladder): 17 people, 44.74%
Nausea (feeling of having an urge to vomit): 17 people, 44.74%
Hypoaesthesia (reduced sense of touch or sensation): 16 people, 42.11%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 15 people, 39.47%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 15 people, 39.47%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 22 people, 57.89%
Migraine (headache): 14 people, 36.84%
Back Pain: 7 people, 18.42%
Flank Pain (a distressing sensation experienced around the lower back and the upper abdomen): 7 people, 18.42%
Oral Candidiasis (fungal infection of mouth): 7 people, 18.42%
Neuralgia (pain in one or more nerves): 7 people, 18.42%
Sleep Disorder: 5 people, 13.16%
Multiple Sclerosis Relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 10.53%
Multiple Myeloma (cancer of the plasma cells): 3 people, 7.89%
Pain: 3 people, 7.89%

* Approximation only. Some reports may have incomplete information.

Do you take Endep and have Constipation?

- Check whether Constipation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Endep:

Endep (1,301 reports)

Constipation treatments and more:

Constipation (337,850 reports)

Browse all side effects of Endep:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Constipation:

Constipation (3,001 drugs)

Browse all the conditions that are associated with Constipation:

Constipation (4,563 conditions)

Drugs similar to Endep and Constipation :

Related publications that referenced our studies

Li W, Lamichhane J, "From Heartbreak to Left Bundle Branch Block: A Case of Amitriptyline Overdose", American Journal of Therapeutics, 2017 Sep .
Li W, Lamichhane J, "From Heartbreak to Left Bundle Branch Block: A Case of Amitriptyline Overdose", American Journal of Therapeutics, 2017 Sep .

How the study uses the data?

The study uses data from the FDA. It is based on amitriptyline hydrochloride (the active ingredients of Endep) and Endep (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.