Endep and Gastric ulcer - a phase IV clinical study of FDA data

Summary:

Gastric ulcer is reported as a side effect among people who take Endep (amitriptyline hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years also take Rinvoq, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Gastric ulcer when taking Endep. It is created by eHealthMe based on reports of 864 people who have side effects when taking Endep from the FDA, and is updated regularly.

What is Endep?

Endep has active ingredients of amitriptyline hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 1,302 Endep users. Check the latest studies of Endep.

What is Gastric ulcer?

Gastric ulcer (stomach ulcer) is found to be associated with 1,953 drugs and 3,385 conditions by eHealthMe. Check the latest studies of Gastric ulcer.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 03, 2026

864 people reported to have side effects when taking Endep.
Among them, 13 people (1.5%) have Gastric ulcer.

Among these 13 people:

How long have people been on Endep when they have Gastric ulcer? *

What is the gender of people who have Gastric ulcer when taking Endep? *

female: 55.56 %
male: 44.44 %

What is the age of people who have Gastric ulcer when taking Endep? *

What are other drugs people take besides Endep? *

What are other side effects people have besides Gastric ulcer? *

Arthritis (form of joint disorder that involves inflammation of one or more joints): 7 people, 53.85%
Muscle Spasms (muscle contraction): 6 people, 46.15%
Pain: 6 people, 46.15%
Dyspnea (difficult or laboured breathing): 6 people, 46.15%
Nausea (feeling of having an urge to vomit): 6 people, 46.15%
Cushingoid (obesity and weakening of the muscles): 5 people, 38.46%
Diarrhea: 5 people, 38.46%
Multimorbidity (co-occurrence of two or more chronic medical conditions in one person): 4 people, 30.77%
Post Inflammatory Pigmentation Change: 4 people, 30.77%
Haematochezia (passage of stools containing blood): 4 people, 30.77%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 46.15%
Pyoderma Gangrenosum (ulcerating condition of skin that results in heaped borders with a typical appearance): 2 people, 15.38%
Pain: 2 people, 15.38%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 2 people, 15.38%

* Approximation only. Some reports may have incomplete information.

Do you take Endep and have Gastric ulcer?

- Check whether Gastric ulcer is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Endep:

Endep (1,302 reports)

Gastric ulcer treatments and more:

Gastric ulcer (113,573 reports)

Browse all side effects of Endep:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Gastric ulcer:

Gastric ulcer (1,953 drugs)

Browse all the conditions that are associated with Gastric ulcer:

Gastric ulcer (3,385 conditions)

Related publications that referenced our studies

Li W, Lamichhane J, "From Heartbreak to Left Bundle Branch Block: A Case of Amitriptyline Overdose", American Journal of Therapeutics, 2017 Sep .
Li W, Lamichhane J, "From Heartbreak to Left Bundle Branch Block: A Case of Amitriptyline Overdose", American Journal of Therapeutics, 2017 Sep .

How the study uses the data?

The study uses data from the FDA. It is based on amitriptyline hydrochloride (the active ingredients of Endep) and Endep (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.