Enskyce and Headache - a phase IV clinical study of FDA data

Summary:

Headache is reported as a side effect among people who take Enskyce (desogestrel; ethinyl estradiol), especially for people who are female, 30-39 old, also take Vitamin D, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Headache when taking Enskyce. It is created by eHealthMe based on reports of 175 people who have side effects when taking Enskyce from the FDA, and is updated regularly.

What is Enskyce?

Enskyce has active ingredients of desogestrel; ethinyl estradiol. It is often used in birth control. eHealthMe is studying from 194 Enskyce users. Check the latest studies of Enskyce.

What is Headache?

Headache (pain in head) is found to be associated with 3,749 drugs and 5,772 conditions by eHealthMe. Check the latest studies of Headache.

On Jul, 16, 2026

175 people reported to have side effects when taking Enskyce.
Among them, 11 people (6.29%) have Headache.

Among these 11 people:

What is the gender of people who have Headache when taking Enskyce? *

female: 100 %
male: 0.0 %

What is the age of people who have Headache when taking Enskyce? *

What are other drugs people take besides Enskyce? *

Zyrtec: 2 people, 18.18%
Ondansetron: 2 people, 18.18%
Dupixent: 2 people, 18.18%
Breo Ellipta: 2 people, 18.18%
Trelegy Ellipta: 2 people, 18.18%
Vitamin B12: 2 people, 18.18%
Asa: 2 people, 18.18%
Vitamin D: 2 people, 18.18%
Cyclobenzaprine Hydrochloride: 1 person, 9.09%
Fasenra: 1 person, 9.09%

What are other side effects people have besides Headache? *

Fatigue (feeling of tiredness): 2 people, 18.18%
Migraine (headache): 2 people, 18.18%
Constipation: 2 people, 18.18%
Nausea (feeling of having an urge to vomit): 2 people, 18.18%
Weight Decreased: 1 person, 9.09%
Hyperkalemia (damage to or disease of the kidney): 1 person, 9.09%
Hyperacusis (disorder in loudness perception): 1 person, 9.09%
Heavy Or Prolong Menstrual Bleeding: 1 person, 9.09%
Hair Loss: 1 person, 9.09%
Haematemesis (vomiting of blood): 1 person, 9.09%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 18.18%
Weight Decreased: 1 person, 9.09%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 9.09%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 1 person, 9.09%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 1 person, 9.09%
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it): 1 person, 9.09%
Cystic Fibrosis (disease of the secretary glands): 1 person, 9.09%
Cushing's Syndrome (obesity, a rounded face, increased fat): 1 person, 9.09%
Cough: 1 person, 9.09%
Asthma: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Enskyce and have Headache?

- Check whether Headache is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Enskyce:

Enskyce (194 reports)

Headache treatments and more:

Headache (756,642 reports)

How severe was Headache and when was it recovered:

Headache in Enskyce

Expand to all the drugs that have ingredients of desogestrel; ethinyl estradiol:

Headache and drugs with ingredients of desogestrel; ethinyl estradiol (958 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Enskyce:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Headache:

Headache (3,749 drugs)

Browse all the conditions that are associated with Headache:

Headache (5,772 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on desogestrel; ethinyl estradiol (the active ingredients of Enskyce) and Enskyce (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.