Entresto and Angiopathy - a phase IV clinical study of FDA data

Summary:

Angiopathy is reported as a side effect among people who take Entresto (sacubitril; valsartan), especially for people who are male, 60+ old, have been taking the drug for 6 - 12 months also take Metformin, and have Cardiac failure.

The phase IV clinical study analyzes which people have Angiopathy when taking Entresto. It is created by eHealthMe based on reports of 126,188 people who have side effects when taking Entresto from the FDA, and is updated regularly.

What is Entresto?

Entresto has active ingredients of sacubitril; valsartan. eHealthMe is studying from 126,628 Entresto users. Check the latest studies of Entresto.

What is Angiopathy?

Angiopathy (generic term for a disease of the blood vessels) is found to be associated with 716 drugs and 881 conditions by eHealthMe. Check the latest studies of Angiopathy.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

126,188 people reported to have side effects when taking Entresto.
Among them, 50 people (0.04%) have Angiopathy.

Among these 50 people:

How long have people been on Entresto when they have Angiopathy? *

What is the gender of people who have Angiopathy when taking Entresto? *

female: 40 %
male: 60 %

What is the age of people who have Angiopathy when taking Entresto? *

What are other drugs people take besides Entresto? *

Jardiance: 4 people, 8.00%
Metformin: 4 people, 8.00%
Amlodipine: 3 people, 6.00%
Carvedilol: 3 people, 6.00%
Lasix: 3 people, 6.00%
Insulin: 1 person, 2.00%
Amiodarone Hydrochloride: 1 person, 2.00%
Breo Ellipta: 1 person, 2.00%
Clopidogrel: 1 person, 2.00%
Coreg: 1 person, 2.00%

What are other side effects people have besides Angiopathy? *

Dyspnea (difficult or laboured breathing): 13 people, 26.00%
Hypotension (abnormally low blood pressure): 12 people, 24.00%
Pain: 11 people, 22.00%
Cardiac Failure: 10 people, 20.00%
High Blood Pressure: 9 people, 18.00%
Gait Disturbance: 8 people, 16.00%
Fall: 8 people, 16.00%
Muscle Spasms (muscle contraction): 7 people, 14.00%
Dizziness: 7 people, 14.00%
Ejection Fraction Decreased (systolic heart failure): 7 people, 14.00%

What are the existing conditions these people have? *

Cardiac Failure: 23 people, 46.00%
Cardiac Failure Congestive: 8 people, 16.00%
Cardiac Failure Chronic: 4 people, 8.00%
Diabetes: 2 people, 4.00%
Chronic Left Ventricular Failure (long lasting functional impairment of left ventricle of heart): 2 people, 4.00%
Sleep Disorder: 1 person, 2.00%
Multiple Myeloma (cancer of the plasma cells): 1 person, 2.00%
Glaucoma (increased fluid pressure in the eye with vision loss): 1 person, 2.00%
Fluid Retention (an abnormal accumulation of fluid in the blood): 1 person, 2.00%
Depression: 1 person, 2.00%

* Approximation only. Some reports may have incomplete information.

Do you take Entresto and have Angiopathy?

- Check whether Angiopathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Entresto:

Entresto (126,628 reports)

Angiopathy treatments and more:

Angiopathy (8,773 reports)

Browse all side effects of Entresto:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Angiopathy:

Angiopathy (716 drugs)

Browse all the conditions that are associated with Angiopathy:

Angiopathy (881 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on sacubitril; valsartan (the active ingredients of Entresto) and Entresto (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.