Entresto and Fluid imbalance - a phase IV clinical study of FDA data

Summary:

Fluid imbalance is reported as a side effect among people who take Entresto (sacubitril; valsartan), especially for people who are male, 60+ old, also take Lasix, and have Cardiac failure.

The phase IV clinical study analyzes which people have Fluid imbalance when taking Entresto. It is created by eHealthMe based on reports of 126,188 people who have side effects when taking Entresto from the FDA, and is updated regularly.

What is Entresto?

Entresto has active ingredients of sacubitril; valsartan. eHealthMe is studying from 126,628 Entresto users. Check the latest studies of Entresto.

What is Fluid imbalance?

Fluid imbalance (imbalance of fluid in body in intake and fluid lost) is found to be associated with 106 drugs and 207 conditions by eHealthMe. Check the latest studies of Fluid imbalance.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

126,188 people reported to have side effects when taking Entresto.
Among them, 65 people (0.05%) have Fluid imbalance.

Among these 65 people:

What is the gender of people who have Fluid imbalance when taking Entresto? *

female: 39.06 %
male: 60.94 %

What is the age of people who have Fluid imbalance when taking Entresto? *

What are other drugs people take besides Entresto? *

What are other side effects people have besides Fluid imbalance? *

Hypotension (abnormally low blood pressure): 16 people, 24.62%
Fatigue (feeling of tiredness): 16 people, 24.62%
Memory Loss: 12 people, 18.46%
Dyspnea (difficult or laboured breathing): 11 people, 16.92%
Weight Increased: 10 people, 15.38%
Dizziness: 9 people, 13.85%
Weight Decreased: 9 people, 13.85%
Weight Fluctuation: 7 people, 10.77%
Malaise (a feeling of general discomfort or uneasiness): 6 people, 9.23%
Stress And Anxiety: 6 people, 9.23%

What are the existing conditions these people have? *

Cardiac Failure: 18 people, 27.69%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 5 people, 7.69%
Urination - Excessive Volume: 4 people, 6.15%
Cardiac Failure Congestive: 3 people, 4.62%
Amyloidosis Senile (common form of amyloidosis in very old people, usually mild and limited to the heart): 2 people, 3.08%
Amyloidosis (a tumour within which amyloid is produced): 2 people, 3.08%
Oedema Peripheral (superficial swelling): 1 person, 1.54%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 1.54%
Diabetes: 1 person, 1.54%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 1 person, 1.54%

* Approximation only. Some reports may have incomplete information.

Do you take Entresto and have Fluid imbalance?

- Check whether Fluid imbalance is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Entresto:

Entresto (126,628 reports)

Fluid imbalance treatments and more:

Fluid imbalance (1,515 reports)

Browse all side effects of Entresto:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Fluid imbalance:

Fluid imbalance (106 drugs)

Browse all the conditions that are associated with Fluid imbalance:

Fluid imbalance (207 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on sacubitril; valsartan (the active ingredients of Entresto) and Entresto (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.