Entresto and Partial seizures - a phase IV clinical study of FDA data

Summary:

Partial seizures is reported as a side effect among people who take Entresto (sacubitril; valsartan), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Edoxaban, and have Atrial fibrillation/flutter.

The phase IV clinical study analyzes which people have Partial seizures when taking Entresto. It is created by eHealthMe based on reports of 126,188 people who have side effects when taking Entresto from the FDA, and is updated regularly.

What is Entresto?

Entresto has active ingredients of sacubitril; valsartan. eHealthMe is studying from 126,628 Entresto users. Check the latest studies of Entresto.

What is Partial seizures?

Partial seizures (seizures which affect only a part of the brain at onset) is found to be associated with 478 drugs and 726 conditions by eHealthMe. Check the latest studies of Partial seizures.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

126,188 people reported to have side effects when taking Entresto.
Among them, 12 people (0.01%) have Partial seizures.

Among these 12 people:

How long have people been on Entresto when they have Partial seizures? *

What is the gender of people who have Partial seizures when taking Entresto? *

female: 77.78 %
male: 22.22 %

What is the age of people who have Partial seizures when taking Entresto? *

What are other drugs people take besides Entresto? *

What are other side effects people have besides Partial seizures? *

Speech Impairment (Adult) (inability to speak (adult)): 10 people, 83.33%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 7 people, 58.33%
Weakness: 7 people, 58.33%
Dementia (madness): 7 people, 58.33%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 7 people, 58.33%
Fungal Nail Infection: 6 people, 50.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 50.00%
General Physical Health Deterioration (weak health status): 6 people, 50.00%
Haematocrit Decreased: 6 people, 50.00%
Haematoma (collection of blood outside the blood vessels): 6 people, 50.00%

What are the existing conditions these people have? *

Cardiac Failure Chronic: 6 people, 50.00%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 50.00%
Cardiac Failure: 4 people, 33.33%
Prostatic Disorder: 3 people, 25.00%
Depression: 3 people, 25.00%
Cardiac Failure Congestive: 3 people, 25.00%
Stable Angina (a constant chest pain): 1 person, 8.33%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1 person, 8.33%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 1 person, 8.33%
High Blood Pressure: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Entresto and have Partial seizures?

- Check whether Partial seizures is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Entresto:

Entresto (126,628 reports)

Partial seizures treatments and more:

Partial seizures (17,458 reports)

Browse all side effects of Entresto:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Partial seizures:

Partial seizures (478 drugs)

Browse all the conditions that are associated with Partial seizures:

Partial seizures (726 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on sacubitril; valsartan (the active ingredients of Entresto) and Entresto (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.