Entresto and Transaminases increased - a phase IV clinical study of FDA data

Summary:

Transaminases increased is reported as a side effect among people who take Entresto (sacubitril; valsartan), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Xarelto, and have Cardiac failure.

The phase IV clinical study analyzes which people have Transaminases increased when taking Entresto. It is created by eHealthMe based on reports of 126,188 people who have side effects when taking Entresto from the FDA, and is updated regularly.

What is Entresto?

Entresto has active ingredients of sacubitril; valsartan. eHealthMe is studying from 126,628 Entresto users. Check the latest studies of Entresto.

What is Transaminases increased?

Transaminases increased is found to be associated with 1,161 drugs and 1,514 conditions by eHealthMe. Check the latest studies of Transaminases increased.

On Jul, 27, 2026

126,188 people reported to have side effects when taking Entresto.
Among them, 38 people (0.03%) have Transaminases increased.

Could Entresto cause Transaminases increased?

Among these 38 people:

How long have people been on Entresto when they have Transaminases increased? *

What is the gender of people who have Transaminases increased when taking Entresto? *

female: 27.78 %
male: 72.22 %

What is the age of people who have Transaminases increased when taking Entresto? *

What are other drugs people take besides Entresto? *

Xarelto: 7 people, 18.42%
Inspra: 5 people, 13.16%
Amaryl: 5 people, 13.16%
Clexane: 3 people, 7.89%
Lasix: 3 people, 7.89%
Diovan: 3 people, 7.89%
Potassium: 3 people, 7.89%
Eliquis: 2 people, 5.26%
Metformin: 2 people, 5.26%
Metformin Hydrochloride: 2 people, 5.26%

What are other side effects people have besides Transaminases increased? *

Cardiac Failure: 13 people, 34.21%
Dyspnea (difficult or laboured breathing): 10 people, 26.32%
Hepatic Failure (liver failure): 10 people, 26.32%
Nausea (feeling of having an urge to vomit): 8 people, 21.05%
Hypotension (abnormally low blood pressure): 7 people, 18.42%
Gamma-Glutamyltransferase Increased: 7 people, 18.42%
Hepatic Function Abnormal: 6 people, 15.79%
Dyspnea Exertional: 6 people, 15.79%
Blood Creatinine Increased: 6 people, 15.79%
Dizziness: 6 people, 15.79%

What are the existing conditions these people have? *

Cardiac Failure: 18 people, 47.37%
Ischaemic Cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease): 7 people, 18.42%
Diabetes: 7 people, 18.42%
Ejection Fraction Decreased (systolic heart failure): 7 people, 18.42%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 6 people, 15.79%
Cardiac Failure Chronic: 6 people, 15.79%
Ventricular Tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart): 5 people, 13.16%
Hyperlipidaemia (presence of excess lipids in the blood): 4 people, 10.53%
Left Ventricular Dysfunction: 3 people, 7.89%
Cardiomyopathy (weakening of the heart muscle): 3 people, 7.89%

* Approximation only. Some reports may have incomplete information.

Do you take Entresto and have Transaminases increased?

- Check whether Transaminases increased is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Entresto:

Entresto (126,628 reports)

Browse all side effects of Entresto:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Transaminases increased:

Transaminases increased (1,161 drugs)

Browse all the conditions that are associated with Transaminases increased:

Transaminases increased (1,514 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on sacubitril; valsartan (the active ingredients of Entresto) and Entresto (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.