Epipen and Hepatomegaly - a phase IV clinical study of FDA data

Summary:

Hepatomegaly is reported as a side effect among people who take Epipen (epinephrine), especially for people who are female, 50-59 old, also take Ondansetron, and have High blood pressure.

The phase IV clinical study analyzes which people have Hepatomegaly when taking Epipen. It is created by eHealthMe based on reports of 23,690 people who have side effects when taking Epipen from the FDA, and is updated regularly.

What is Epipen?

Epipen has active ingredients of epinephrine. It is often used in anaphylaxis. eHealthMe is studying from 23,760 Epipen users. Check the latest studies of Epipen.

What is Hepatomegaly?

Hepatomegaly (abnormal enlargement of the liver) is found to be associated with 1,305 drugs and 1,925 conditions by eHealthMe. Check the latest studies of Hepatomegaly.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

23,690 people reported to have side effects when taking Epipen.
Among them, 18 people (0.08%) have Hepatomegaly.

Among these 18 people:

What is the gender of people who have Hepatomegaly when taking Epipen? *

female: 61.11 %
male: 38.89 %

What is the age of people who have Hepatomegaly when taking Epipen? *

What are other drugs people take besides Epipen? *

What are other side effects people have besides Hepatomegaly? *

Fatigue (feeling of tiredness): 7 people, 38.89%
Malaise (a feeling of general discomfort or uneasiness): 6 people, 33.33%
Dyspnea (difficult or laboured breathing): 6 people, 33.33%
Diarrhea: 6 people, 33.33%
Nausea And Vomiting: 5 people, 27.78%
Peripheral Swelling: 5 people, 27.78%
Joint Swelling: 5 people, 27.78%
Pain: 5 people, 27.78%
High Blood Pressure: 5 people, 27.78%
Urinary Tract Infection: 5 people, 27.78%

What are the existing conditions these people have? *

Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 16.67%
Systemic Mastocytosis (a condition caused by the accumulation of mast cells in more than one part of the body): 3 people, 16.67%
Hereditary Angioedema (recurrent episodes of severe swelling): 3 people, 16.67%
High Blood Pressure: 3 people, 16.67%
Back Pain: 2 people, 11.11%
Chest Pain: 2 people, 11.11%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 11.11%
Insomnia (sleeplessness): 2 people, 11.11%
Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 11.11%
T-Cell Type Acute Leukaemia (a form of cancer of the white blood cells): 2 people, 11.11%

* Approximation only. Some reports may have incomplete information.

Do you take Epipen and have Hepatomegaly?

- Check whether Hepatomegaly is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Epipen:

Epipen (23,760 reports)

Hepatomegaly treatments and more:

Hepatomegaly (20,071 reports)

Browse all side effects of Epipen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hepatomegaly:

Hepatomegaly (1,305 drugs)

Browse all the conditions that are associated with Hepatomegaly:

Hepatomegaly (1,925 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on epinephrine (the active ingredients of Epipen) and Epipen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.